Copyright
©The Author(s) 2022.
World J Nephrol. Mar 25, 2022; 11(2): 58-72
Published online Mar 25, 2022. doi: 10.5527/wjn.v11.i2.58
Published online Mar 25, 2022. doi: 10.5527/wjn.v11.i2.58
Table 1 Comparison of demographics and baseline characteristics of patients grouped by outcome
Total patients, n (%) | Survivors, n (%) | Non-survivors, n (%) | P value | Non-progressors, n (%) | Progressors, n (%) | P value | |
Characteristic | 32 (100) | 27 (84.4) | 5 (15.6) | 19 (59.3) | 13 (40.6) | ||
Male | 17 (53.1) | 16 (59.3) | 1 (20) | NS | 9 (47.4) | 8 (61.5) | NS |
Female | 15 (46.9) | 11 (40.7) | 4 (80) | 10 (52.6) | 5 (38.5) | ||
1Age | 75.5 (58.5-82) | 75 (56-82) | 76 (75-80) | NS | 70 (53-82) | 78 (75-82) | NS |
1Frailty index | 3 (2-5) | 3 (2-5) | 7 (3-8) | < 0.05 | 3 (2-5) | 3 (2-5) | NS |
CT (%) | < 0.01 | NS | |||||
0-10% | 24 (77.4) | 23 (88.5) | 1 (20) | 16 (84.2) | 8 (66.7) | ||
> 10% | 7 (22.6) | 3 (11.5) | 4 (80) | 3 (15.8) | 4 (33.3) | ||
WHΟ | 0.05 | NS | |||||
0 | 16 (50) | 15 (55.6) | 1 (20) | 11 (57.8) | 5 (38.5) | ||
1 | 13 (40.6) | 11 (40.7) | 2 (40) | 8 (42.1) | 5 (38.5) | ||
2-3 | 3 (9.4) | 1 (3.7) | 2 (40) | 0 (0) | 3 (23) | ||
Diabetes | 10 (31.3) | 7 (25.9) | 3 (60) | NS | 7 (36.8) | 3 (23.1) | NS |
Hypertension | 20 (62.5) | 18 (66.7) | 2 (40) | NS | 11 (57.8) | 9 (69.2) | NS |
1Number of comorbidities | 3 (2-3.5) | 3 (2-4) | 3 (2-3) | NS | 3 (1-4) | 3 (2-3) | NS |
Symptoms | NS | NS | |||||
Fever | 13 (65) | 10 (62.5) | 3 (75) | 8 (80) | 5 (50) | ||
Respiratory | 6 (30) | 5 (31.2) | 1 (25) | 1 (10) | 5 (50) | ||
Diarrhea | 1 (5) | 1 (6.3) | 0 (0) | 1 (10) | 0 (0) | ||
COVID diagnosis | NS | NS | |||||
With symptoms | 20 (62.5) | 16 (59.3) | 4 (80) | 10 (52.6) | 10 (76.9) | ||
Screening | 12 (37.5) | 11 (40.7) | 1 (20) | 9 (47.4) | 3 (23.1) |
Table 2 Comparison of characteristics of patients grouped by World Health Organization coronavirus disease 2019 severity
Disease severity | Mild (16/32) | Moderate/severe (16/32) | P value |
Median (IQR) | Median (IQR) | ||
Age (yr) | 77.5 (54.5-84.5) | 75.5 (67.5-78.5) | NS |
Frailty index | 3.5 (2-5) | 3 (2-4.5) | NS |
Co-morbidities | 3 (1-3) | 3 (2-4) | NS |
Men, n (%) | 7 (43.8) | 10 (62.5) | NS |
Women, n (%) | 9 (56.2) | 6 (37.5) | |
Screening, n (%) | 11 (68.8) | 1 (6.3) | < 0.01 |
Symptomatic, n (%) | 5 (31.2) | 15 (93.7) | |
CT infiltrates | NS | ||
0-10% | 13 (86.7) | 11 (68.8) | |
> 10% | 2 (13.3) | 5 (31.2) | |
COVID death, n (%) | 0 (0) | 3 (21.4) | NS |
Non-COVID death, n (%) | 1 (7.1) | 1 (9.1) | NS |
COVID progression, n (%) | 5 (31.3) | 8 (50) | NS |
Table 3 Comparison of laboratory measurements between patients with different coronavirus disease 2019 outcomes
Variable | Survival status | Respiratory progression due to COVID-19 | |||||
Total (n = 32) | Survivors | Non-survivors | P value | No (n = 19) | Yes (n = 13) | P value | |
Median (IQR) | Median (IQR) | ||||||
Lymphocytes (k/μL) | |||||||
On admission | 0.9 (0.8-1.4) | 1 (0.8-1.4) | 0.6 (5.3-1.3) | NS | 1 (0.8-1.5) | 0.8 (0.5-1.3) | NS |
Highest value of 10 d | 1.4 (1-1.7) | 1.3 (1-1.7) | 2.5 (1.4-3.4) | NS | 1.4 (1.2-1.8) | 0.9 (0.5-1.5) | NS |
Increase (%) | 10.4 (-2.3-51.6) | 10.3 (-2.6-42.7) | 60.8 (6.8-365.1) | NS | 37.6 (5.4-83.2) | 6.8 (-9.4-10.6) | NS |
CRP (mg/L) | |||||||
On admission | 19.3 (9.6-47.7) | 17.2 (8.1-88.2) | 22 (19.3-41.8) | NS | 17.2 (8.1-41.2) | 32.8 (10.6-88.2) | NS |
Highest value of 10 d | 55.6 (15.5-111.5) | 55.2 (15.1-108) | 83.5 (31.9-220) | NS | 34.8 (10.6-79) | 92 (31.9-149) | NS |
Increase (%) | 61.6 (-8.2-312.6) | 54.3 (-0.9-308.8) | 426.3 (-36.3-435.3) | NS | 45 (-15.5-160.4) | 300.9 (0-513.2) | NS |
WBC (mg/L) | |||||||
On admission | 5.9 (4.7-7.9) | 5.9 (4.5-8) | 6.2 (5.3-7.7) | NS | 5.9 (4.8-7.7) | 5.9 (4.2-8.8) | NS |
Highest value of 10 d | 7 (5.4-10.4) | 7 (5.3-10) | 9.4 (8-10.8) | NS | 6.9 (5.3-9.4) | 8 (5.9-12.6) | NS |
Increase (%) | 16.9 (-2.5-73.2) | 15.4 (-2.9-44.5) | 88.1 (21.4-103.8) | NS | 15.4 (0-36.4) | 74.9 (-10.1-103.8) | NS |
Neutrophils (k/μL) | |||||||
On admission | 4 (2.8-5.8) | 4 (2.8-5.8) | 3.8 (3.7-4.4) | NS | 3.8 (2.5-4.7) | 4.9 (3.4-6.7) | NS |
Highest value of 10 d | 5.3 (3.2-7.3) | 4.8 (3.1-7.3) | 5.6 (5.5-7.3) | NS | 4.6 (2.7-5.6) | 6.8 (5.3-9.6) | < 0.05 |
Increase (%) | 19.7 (-1.8-82.9) | 16.7 (-1.8-73.3) | 47.6 (19.8-154.8) | NS | 18.7 (3.3-39.8) | 102.4 (-6.8-162.8) | NS |
NLR | |||||||
On admission | 4.4 (2.9-6.5) | 4.1 (2.9-6.4) | 5.6 (2.8-7.1) | NS | 3.7 (2.6-6) | 4.9 (4.1-8.2) | NS |
Highest value of 10 d | 5 (2.7-10.6) | 4.7 (2.7-10.2) | 10 (3.3-14.6) | NS | 3.3 (2-5.3) | 13.4 (7.7-26.3) | < 0.01 |
Increase (%) | 17.8 (-12.8-116.1) | 18.4 (-14-65.6) | 6.4 (3.9-263.6) | NS | 2.5 (-31.8-25.9) | 235.9 (18.4-394.4) | < 0.01 |
Albumin (g/dL) | |||||||
On admission | 3.8 (3.5-4.1) | 3.8 (3.5-4.1) | 3.9 (3.7-4) | NS | 3.8 (3.5-4.1) | 3.9 (3.5-4) | |
Lowest value of 10 d | 3.3 (2.9-3.7) | 3.5 (2.9-3.7) | 2.9 (2.7-3.1) | < 0.05 | 3.3 (2.8-3.7) | 3.2 (2.9-3.5) | NS |
Decrease (%) | 12.1 (3.6-20.5) | 10 (3.6-18.8) | 25.6 (16.2-26.7) | NS | 10 (3.6-18.8) | 17.1 (7.7-20.5) | NS |
Ferritin (ng/mL) | |||||||
On admission | 448 (241.5-911) | 459 (249-940) | 408 (224-745) | NS | 341 (202-940) | 745 (369-904) | NS |
Highest value of 10 d | 1018 (445.5-1507) | 1038 (428-1559) | 605 (520-666) | NS | 548 (295-1455) | 1102 (666-1837) | NS |
Increase (%) | 49.3 (24.5-129.5) | 54.8 (26.3-129.2) | 27.5 (-21.9-146.6) | NS | 30.2 (26.3.4-97.7) | 129.7 (12.4-197.3) | NS |
LDH (U/L) | |||||||
On admission | 216 (174-285) | 222 (175-276) | 207 (174-298) | NS | 216 (158-297) | 217.5 (193-232.5) | NS |
Highest value of 10 d | 227 (183-273) | 225.5 (183-256) | 313 (272-330) | < 0.05 | 224 (184-256) | 261 (177.5-321.5) | NS |
Increase (%) | 5.7 (-13.8-60.6) | 5.6 (-13.8-25.2) | 89.7 (5-95.7) | < 0.05 | 5.8 (-14.7-25.2) | 5 (-11.6-89.7) | NS |
Ddimers (ng/mL) | |||||||
On admission | 1325 (772-2841) | 1080 (772-21562349 | 3089 (1244-5205) | NS | 1080 (732-3136) | 1640 (996-2349) | NS |
Highest value of 10 d | 1861.5 (1215-3503) | 1624 (1073-2526) | 3503 (3447-5032) | <0.05 | 1624 (1259-3191) | 2526 (1073-4134) | NS |
Increase (%) | 13 (-1.6-61.2) | 7.3 (-1.6-41.2) | 82.6 (19.1-195.8) | NS | 18.5 (0-52) | 1.4 (-21.3-104.3) | NS |
Troponin | |||||||
On admission | 72.3 (33.6-99.6) | 72.9 (26.9-102) | 71.4 (53-86.7) | NS | 53 (25.8-84.4) | 86.7 (49.8-102) | NS |
Highest value of 10 d | 84.6 (46.7-116) | 84.4 (38.3-118) | 92.6 (62-114) | NS | 66.5 (29.4-108) | 103 (83.2-118) | NS |
Increase (%) | 17.7 (2-39.6) | 17.6 (1-45) | 29.7 (17.3-31.5) | NS | 17.6 (1-50.4) | 29.7 (2.9-34.1) | NS |
- Citation: Bacharaki D, Karagiannis M, Sardeli A, Giannakopoulos P, Tziolos NR, Zoi V, Piliouras N, Arkoudis NA, Oikonomopoulos N, Tzannis K, Kavatha D, Antoniadou A, Vlahakos D, Lionaki S. Clinical presentation and outcomes of chronic dialysis patients with COVID-19: A single center experience from Greece . World J Nephrol 2022; 11(2): 58-72
- URL: https://www.wjgnet.com/2220-6124/full/v11/i2/58.htm
- DOI: https://dx.doi.org/10.5527/wjn.v11.i2.58