Should pediatric idiopathic hypercalciuria be treated with hypocalciuric agents?

Table 1 Demographic variables in G1 and G2

	Age (yr), mean ± SD	Gender, M/F	BMIz-score before, mean ± SD	BMIz-score after, mean ± SD
G1 (n = 9)	9.11 ± 2.57	4/5	-0.74 ± 0.76	-0.80 ± 0.76
G2 (n = 31)	10.09 ± 3.65	18/13	-0.82 ± 2.06	-0.63 ± 1.15
P value	NS	NS	10.72	10.80

¹T test. There were no differences in age, gender, body mass index z-score, and biochemical parameters between G1 and G2. There were no increases in total cholesterol and in low-density lipoprotein-cholesterol as well as hypokalemia and hypomagnesemia. BMI: Body mass index; F: Female; M: Male.

Table 2 Biochemical variables in G1 and G2

	Calciuria before (mg/kg per 24 h)	Calciuria after (mg/kg per 24 h)	P value
G1 (n = 9), mean ± SD	5.12 ± 0.84	2.57 ± 0.82	10.0004
G2 (n = 31), median (Min-Max)	5.2 (4.3-7.0)	2.9 (2.0-4.3)	20.001

¹T test (normal distribution).

²Wilcoxon test (abnormal distribution). Calciuria was significantly lower after treatment in G1 as well as in G2.