Role of renal proximal tubule transport in thiazolidinedione-induced volume expansion

Table 1 Summary of results about mechanism of thiazolidinedione-induced volume expansion

Ref.	Cells/animals	Results
Guan et al[12]	Collecting duct-specific PPARγ KO mouse	TZD-induced volume expansion is dependent on PPARγ in collecting ducts. Increase in collecting duct Na transport and ENaCγ mRNA by TZDs
Zhang et al[13]	Collecting duct-specific PPARγ KO mouse	TZD-induced volume expansion is dependent on PPARγ in collecting ducts. Increase in collecting duct Na transport by TZDs
Hong et al[14]	Collecting duct cells	Increase in cell surface ENaC expression by TZDs
Nofziger et al[15]	Collecting duct cells	No effects of TZDs on ENaC activity
Song et al[16]	Rat	Increase in expression of Na/K ATPase and NHE3 but not of ENaC by TZDs
Vallon et al[17]	Collecting duct-specific ENaC KO mouse	ENaC-independent volume expansion by TZDs
Borsting et al[18]	M1 collecting duct cells	Suppression of ENaCγ promoter by TZDs
Endo et al[26]	Isolated PT from rabbit, rat, and human	Non-genomic stimulation of PT transport by TZDs
Saad et al[29]	Human PT cells	Sgk-1-dependent stimulation of NHE3 expression by TZDs

TZDs: Thiazolidinediones; PPARγ: Peroxisome-proliferator-activated receptors γ; PT: Proximal tubule.