Severe cyclophosphamide-related hyponatremia in a patient with acute glomerulonephritis

Figure 1 Histological examination showed glomeruli with mesangial expansion and endocapillary hypercellularity with some karyorrhectic bodies, fibrinoid necrosis of small arterioles, and fibrocellular crescents (as shown in the figure-PAS, x 400).

Figure 2 Time trend of serum sodium concentration and urinary osmolality following cyclophosphamide administration. During days 3 and 4 the urinary osmolality was inappropriately high considering the hyponatremia. In days 5 to 9 the urinary dilution capacity was re-established.