Immunofluorescence-based reclassification of idiopathic membranoproliferative glomerulonephritis: Insights from a single-center cohort

Figure 1 Immunopathology of complement-mediated membranoproliferative glomerulonephritis A: Mesangial and endocapillary hypercellularity with lobular accentuation (hematoxylin and eosin, × 400); B: Mesangial proliferation with almost diffuse inter-positioning into peripheral capillary loops (periodic acid-Schiff stain, × 400); C: Mesangiocapillary proliferation with double contour formation exhibiting tram track appearance (silver methenamine stain, × 400); D: Diffuse, bright, ring-like positivity of C3 with an intensity of 3+ on a scale of 0-3, predominantly in the mesangium on immunofluorescence. The rest of the immunoreactions were two orders of magnitude lower in intensity (≤ 1+; immunofluorescence, × 400).

Figure 2 Kaplan-Meier survival analysis curves. A comparison of survival rates between immune complex-mediated membranoproliferative glomerulonephritis and complement-mediated membranoproliferative glomerulonephritis patients analyzed using the log-rank test. IC-MPGN: Immune complex-mediated membranoproliferative glomerulonephritis; C-MPGN: Complement-mediated membranoproliferative glomerulonephritis.