Renal involvement in Fabry disease from Tunisian families: Six case reports

Figure 1 Masson’s trichrome stain, × 400. A: The biopsy shows markedly enlarged podocytes with cytoplasm distended by numerous large vacuoles of varying sizes. This vacuolation pattern creates a honeycomb-like appearance, which is characteristic of sphingolipid accumulation, a hallmark of Fabry disease; B: The cytoplasm of distal tubular epithelial cells shows marked vacuolation, consistent with sphingolipid accumulation; C: The interlobular artery shows mild fibrous endarteritis, with multiple vacuoles visible in the myocytes. The arrows highlight characteristic vacuolization features.