Esposito P, Picciotto D, Cappadona F, Costigliolo F, Russo E, Macciò L, Viazzi F. Multifaceted relationship between diabetes and kidney diseases: Beyond diabetes. World J Diabetes 2023; 14(10): 1450-1462 [PMID: 37970131 DOI: 10.4239/wjd.v14.i10.1450]
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October 28, 2023, 12:34
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Reader Comments:
This article discusses the multifaceted association between diabetes mellitus and kidney disease in terms of clinical presentation, differential diagnosis, and new therapeutic opportunities, which are of great clinical guidance.
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03967085
Submitted on:
October 25, 2023, 14:36
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Reader Comments:
Comprehensive and informative paper.
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03887887
Submitted on:
October 22, 2023, 03:34
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Reader Comments:
This article relates diabetes and kidney disease together, and proposes that accurate diagnosis of diabetes and kidney disease has important clinical significance, which will guide the clinical treatment of different patients. In terms of diagnosis, some new biomarkers have been proposed based on previous kidney biopsies, but currently, due to issues such as inconvenient operation and cost, the feasibility of these new testing techniques in clinical practice is limited.
In the second aspect, the article also discussed the risk of new DM in patients with immune mediated kidney disease without diabetes or diabetes nephropathy in the past. It is mentioned in the article that about 10% -20% of patients with glomerulonephritis may develop into diabetes, which may be related to changes in the function of the glomerulus and renal tubules, and then cause a series of metabolic syndrome. This perspective has aroused my interest and I would like to learn more about the relevant mechanisms. However, this article does not elaborate on the pathophysiological mechanisms, but mainly describes the elevated blood sugar levels caused by adverse drug reactions in these patients after using immunosuppressants. This is not representative. Other diseases treated with immunosuppressants may also lead to new type 2 diabetes.
In the third aspect, the anti diabetes drugs were tested, and the drugs showed renal protection. This view triggered my thinking. If we use the above hypoglycemic drugs and immunosuppressants together in the treatment of primary kidney diseases, whether it is possible to reduce the side effects of immunosuppressants on glucose raising, so as to reduce the possibility of older patients with kidney disease and type 2 diabetes secondary to immunosuppressants, we can carry out cohort studies on this aspect.
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Submitted on:
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Reader Comments:
This is a very nice article. However, it would have been better if there is a diagram that would have describe the m
ultifaceted relationship between diabetes and kidney diseases in summary. Authors should have also included one paragraph on the limitations and future perspective. One table for the drugs would have made easy to read and understand. Language is sometimes not easy to understand and at few places the flow in the story is very complex. This make it difficult to understand what authors want to say.
Reply from the Editorial Office:
First, thank you very much for your professional comments on the article published in World Journal of Diabetes.
Second, we read your comments with great interest. You are welcome to format your valuable comments into a Letter to the Editor and submit it online to World Journal of Diabetes at https://www.f6publishing.com. There are no restrictions on the number of words, figures (color, B/W) or authors for a Letter to the Editor. In addition, the article processing charge will be exempted for this Letter to the Editor. As with all articles published by the Baishideng Publishing Group, the Letter to the Editor will be published online after completing peer review. The guidelines for a Letter to the Editor can be found at: https://www.wjgnet.com/bpg/GerInfo/219.
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Submitted on:
October 18, 2023, 11:20
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Reader Comments:
This article provides a comprehensive and in-depth review of the complex and multifaceted relationship between diabetes and kidney disease, including clinical manifestations, disease progression, differential diagnosis, and therapeutic opportunities offered by new drugs. However, it should be noted that some of the cited references are not up-to-date articles, and the author's language is not concise and clear in certain aspects.
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