Review
Copyright ©The Author(s) 2019.
World J Transplant. Oct 28, 2019; 9(6): 103-122
Published online Oct 28, 2019. doi: 10.5500/wjt.v9.i6.103
Table 1 Therapeutic apheresis techniques performed in the setting of kidney transplantation
TPE
cTPE
mTPE
Selective therapeutic apheresis techniques
DFPP
IA
IA using immobilized antibodies
IA using immobilized staphylococcal protein A
IA using immobilized antigens and synthetic epitopes
ECP
TPE: Therapeutic plasma exchange; cTPE: Centrifugal therapeutic plasma exchange; mTPE: Membrane therapeutic plasma exchange; DFPP: Double filtration plasmapheresis; IA: Immunoadsorption; ECP: Extracorporeal photopheresis.
Table 2 Clinical indications for therapeutic apheresis in kidney transplantation
Desensitization in ABO-i kidney transplantation
Desensitization in patients with preformed HLA-antibodies
Desensitization of deceased donor kidney transplant recipients
Desensitization of living donor kidney transplant recipients
AMR
Recurrence of primary FSGS
Prevention of recurrence and recurrence of complement-mediated aHUS
De novo TMA
Antiphospholipid syndrome and systemic lupus erythematosus
Recurrent and de novo anti-GBM disease
Recurrence of ANCA- AAVs
ABOi: ABO incompatible; HLA: Human leukocyte antigens; AMR: Antibody-mediated rejection; FSGS: Focal segmental glomerulosclerosis; aHUS: Atypical haemolytic uremic syndrome; TMA: Thrombotic microangiopathy; GBM: Glomerular basement membrane; ANCA: Antineutrophil cytoplasmic antibody; AAVs: ANCA associated vasculitis.