Kidney transplantation in older recipients: Preemptive high KDPI kidney vs lower KDPI kidney after varying dialysis vintage

Table 1 Demographics

	Preemptive-high KDPI(n = 350)	1-4 yr dialysis vintage-lower KDPI (n = 3300)	Preemptive-high KDPI(n = 350)	4-8 yr dialysis vintage-lower KDPI (n = 2460)
KDPI	93 ± 4	62 ± 14	93 ± 4	62 ± 9
Dialysis duration (mo)	0	31 ± 10	0	67 ± 13
Age (donor)	61 ± 12	46 ± 13b	61 ± 12	46 ± 14b
Donor gender (M) %	46.8	56d	46.8	54.3a
DCD kidney (%)	8.6	14.4d	8.6	14.9d
ECD kidney (%)	89.4	25.6b	89.4	26b
HLA mismatch	4.5 ± 1.3	3.9 ± 1.7b	4.5 ± 1.3	4.3 ± 1.4a
Recipient age (years ± SD)	69 ± 5	67 ± 4a	69 ± 5	67 ± 4b
Recipient gender (M) %	52.4	63.5b	52.4	64b
African American Recipient (%)	14.7	20.9a	14.7	30.8b
Recipient diabetes (%)	30.4	51b	30.4	52.5b
Recipient BMI (%)	27 ± 4	28 ± 5a	27 ± 4	28 ± 5
Calculated PRA	4.6 ± 14	10 ± 25b	4.6 ± 14	13 ± 27b
Cold ischemia time (h)	19 ± 8	18 ± 9	19 ± 8	18 ± 9
Delayed graft function (%)	5.3	29b	5.3	37.5b
Depleting induction (%)	65.5	69.8	65.5	71.5a
Steroid maintenance (%)	64	69.6a	64	70.2a
Kidney pumped (%)	53.7	42.2b	53.7	44d
Transplant year	2009 ± 4	2008 ± 4a	2009 ± 4	2010 ± 3b

^aP ≤ 0.05,

^bP ≤ 0.001,

^dP ≤ 0.005, vs preemptive-high KDPI kidneys. BMI: Body mass index; DCD: Donation after cardiac death; ECD: Expanded criteria donor; HLA: Human leukocyte antigen; KDPI: Kidney donor profile index; PRA: Panel reactive antibody.

Table 2 Comparison of graft and patient outcomes between the groups

	Preemptive-high KDPI (n = 349) vs 1-4 yrdialysis vintage-lower KDPI (n = 3300)		Preemptive-high KDPI (n = 349) vs 4-8 yrdialysis vintage-lower KDPI (n = 2460)
Adjusted overall graft failure risk	1.01 (0.90-1.14)	0.84	0.82 (0.63-1.07)	0.15
Adjusted death censored graft failure risk	0.96 (0.79-1.16)	0.66	0.81 (0.52-1.25)	0.33
Adjusted patient death risk	0.99 (0.87-1.12)	0.89	0.74 (0.56-0.98)	0.04

KDPI: Kidney donor profile index.