Single vs dual (en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience

Table 1 Donor, transplant and recipient characteristics

Mean ± SD	Dual en bloc KT n = 34	Single KT n = 25	P value
Donor age (yr)	1.4 ± 0.8	3.3 ± 1.2	< 0.001
Donor gender: Male	17 (50%)	21 (84%)	0.01
Donor: African American	13 (38%)	7 (28%)	NS
Donor weight (kg)	11.0 ± 2.6	17.4 ± 3.1	0.046
Import organ (non-local)	17 (50%)	14 (56%)	NS
Calculated CrCl (mL/min)	99 ± 50	111 ± 60	NS
Pre-retrieval SCr (mg/dL)	0.37 ± 0.26	0.49 ± 0.24	NS
DCD donors	6 (17.6%)	3 (12%)	NS
Cause of death: Trauma	19 (56%)	11 (44%)	NS
Cold ischemia time (h)	21.0 ± 7.8	20.9 ± 6.4	NS
KDPI (%)	73.2 ± 9.1	62.2 ± 10.4	NS
HLA-mismatch	4.2 ± 1.4	4.2 ± 1.4	NS
0-Antigen mismatch	0	1 (4%)	NS
0% PRA	30 (88%)	24 (96%)	NS
PRA > 40%	2 (5.9%)	1 (4%)	NS
CMV donor+/recipient-	5 (14.7%)	2 (8%)	NS
Retransplant	1 (3%)	3 (12%)	NS
Recipient age (yr)	38.0 ± 12.1	45.7 ± 16.1	0.040
Recipient gender: Male	21 (62%)	13 (52%)	NS
Recipient: African American	17 (50%)	12 (48%)	NS
Recipient weight (kg)	72.2 ± 14.7	75.2 ± 12.0	NS
Recipient with diabetes	6 (17.6%)	6 (24%)	NS
Preemptive transplant	4 (11.8%)	5 (20%)	NS
Duration of dialysis Pretransplant (mo)	41.2 ± 27.2	43.5 ± 32.6	NS
Waiting time (mo)	25.2 ± 13.6	25.4 ± 27.2	NS

CrCl: Creatinine clearance; KT: Kidney transplantation; SCr: Serum creatinine; DCD: Donation after cardiac death; KDPI: Kidney Donor Profile Index; HLA: Human leukocyte antigen; PRA: Panel reactive antibody; NS: Not significant.

Table 2 Results

Mean ± SD	Dual en bloc KT n = 34	Single KT n = 25	P value
Patient survival	32 (94.1%)	20 (80%)	0.12
Graft survival	31 (91.2%)	17 (68%)	0.04
Follow-up (mo)	52 ± 38	74 ± 41	NS
Death-censored graft survival	31/33 (93.9%)	17/21 (81%)	0.19
DWFG	1 (3%)	4 (16%)	0.15
Months to DWFG	15	54 ± 6.5	NS
Delayed graft function	4 (11.8%)	5 (20%)	NS
# Days to SCr < 3.0 mg/dL	4.7 ± 4.5	8.9 ± 7.2	NS
Initial length of stay (d)	5.4 ± 2.9	5.6 ± 3.4	NS
Acute rejection in 1st year	2 (5.9%)	4 (16%)	NS
Surgical complications	1 (2.9%)	1 (4%)	NS
12 mo SCr (mg/dL)	1.17 ± 0.3	1.35 ± 0.3	NS
12 mo GFR (mL/min per 1.73 m2)	72.5 ± 18.4	60.5 ± 18.1	NS
4 yr SCr (mg/dL)	1.0 ± 0.4	1.17 ± 0.4	NS
4 yr GFR (mL/min per 1.73 m2)	81 ± 21.9	64.4 ± 18.1	NS

KT: Kidney transplantation; SCr: Serum creatinine; DWFG: Death with a functioning graft; GFR: Glomerular filtration rate; NS: Not significant.