Pancreas transplantation in type II diabetes mellitus

Table 1 Epidemiologic features differentiating type 1 from type 2 diabetes mellitus

Characteristic	Type 1 DM	Type 2 DM
Age (yr, at diagnosis)	< 25	> 25
Onset	Abrupt	Gradual
Body Habitus	Lean (weight < 105% of IBW)	Overweight/Obese (weight > 115% of IBW)
HLA-association	Yes	No
C-peptide	Undetectable	Detectable
Ketoacidosis	Yes	No
Immediate need for insulin	Yes	No

DM: Diabetes mellitus; IBW: Ideal body weight; HLA: Human leukocyte antigen.

Table 2 Proposed simultaneous pancreas-kidney type 2 diabetic selection criteria

Age < 55 yr

BMI < 30 kg/m2

Insulin dependence

Total insulin requirements < 1 U/kg of IBW/d

Presence of renal failure (dialysis dependent or pre-dialysis advanced diabetic nephropathy with GFR ≤ 20 mL/min per 1.73 m2

Fasting c-peptide < 10 ng/mL

Low cardiac and vascular disease risk

History of medical and dietary compliance

IBW: Ideal body weight; GFR: Glomerular filtration rate.