Islet transplantation-immunological challenges and current perspectives

Table 1 Islet transplantation protocols

Ref.	Patients (n)	Time of infusion of islets (h)	HbA1c, 1-yr, median (%)	HbA1c, 2-yr, median (%)	Insulin independence 1-yr, median (%)	Insulin independence 2-yr, median (%)	IEQ harvested/g pancreas, median (range)	IEQ transplanted/g pancreas, median (range)	Opioid and pain-relieving	Organ placement
Sutherland et al[56]	173	2-7	NR	NR	32	24	< 1000 IE/kg	(> 5000, 2500-5000 and < 2500 IE/kg)	NR	173 liver
Ahmad et al[57]	45	7-10	NR	NR	40	NR	NR	297889 ± 49480	72%	45 liver
Rodriguez Rilo et al[58]	22	9	NR	NR	41	NR	245457 (range 20850 to 607466-175234)	350428 (range 31500 to 1164000-299321	82%	22 liver
Webb et al[59]	46	NR	7	6.7	12	5	1876 (249-12271)	I130029 (24332-958078)	NR	42 liver; 2 spleen; 2 both
Garcea et al[60]	50	NR	Approximately 6	Approximately 6	24	10	NR	NR	60%	85 liver
Johnston et al[55]	36	8-9	NR	6.8	50	33	358959 (45000–672000)	4308 (769–9942)	30%	36 spleen

HbA1c: Hemoglobin A1c; IEQ: Indoor environmental quality. NR: Not reported.