Hemodynamic management in brain dead donors

Table 1 Donor management goals

Goals	Monitoring
MAP ≥ 65 mmHg	Invasive arterial pressure
CVP ≥ 10	Central venous catheter
Hemoglobin ≥ 10 g/dL	Blood gas analysis
Diuresis ≥ 1 mL/kg/h
Na 135-155 meq/L

MAP: Mean arterial pressure; CVP: Central venous pressure.

Table 2 Vasoactive drugs and hormonal therapy in brain death donors–proposed regimen

	Dosage	Comments
Vasoactive
Norepinephrine (mcg/kg/min)	≤ 0.2 mcg/kg/min, if higher dosage needed add vasopressin	In potential heart donors, the lowest dosage is preferable
Vasopressin (U/h)	Up to 2.5 U/h
Hormonal replacement therapy
Idrocorticosteroid	100 mg bolus, 200 mg/24 h infusion
T3	4 mcg intravenous bolus, followed by infusion of 3 mcg per hour	T3 could be preferred since it is immediately available to tissues
Desmopressin (DDVAP)	4 mcg intravenous bolus eventually repeat every 6 to 8 h as needed

DDVAP: 1-deamino-8-D-arginine vasopressin.