Cytomegalovirus infection after liver transplantation

Table 1 Risk of cytomegalovirus infection based on donor and recipient serostatus

Donor	Recipient	Risk	Recommended prophylaxis length
Positive	Negative	Highest	6 months
Positive	Positive	Higher	3 months
Negative	Positive	Moderate	3 months
Negative	Negative	Low	Not recommended

Table 2 Antiviral drugs for cytomegalovirus prophylaxis and treatment in liver transplant patients

Drug	Route	Prophylaxis dose	Treatment dose	Side effects
Ganciclovir	IV	5 mg/kg daily	5 mg/kg twice a day	Bone marrow suppression
Valganciclovir	Oral	900 mg once a day	900 mg twice a day	Leukopenia
Foscarnet	IV	-	60 mg/kg every 8 h or 90 mg/kg every 12 h	Nephrotoxicity
Cidofovir	IV	-	5 mg/kg weekly × 2, then every 2 wk	Nephrotoxicity