Machine perfusion of the liver: Which is the best technique to mitigate ischaemia-reperfusion injury?

Figure 1 Mechanistic characteristic of the different periods of the ischaemia-reperfusion injury and the role of the diverse techniques of machine perfusion of the liver. Techniques leading to reperfusion of the liver during machine perfusion include in situ normothermic regional perfusion and ex situ normothermic machine perfusion; techniques that do not lead to reperfusion of the liver during machine perfusion include hypothermic machine perfusion, subnormothermic machine perfusion and controlled oxygenated rewarming.