C3 glomerulopathy in transplant “like yet unlike native”: Pathophysiology, recent advances in therapeutics and evolving paradigms

doi:10.5500/wjt.v16.i2.117138

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Transplant. Jun 18, 2026; 16(2): 117138
Published online Jun 18, 2026. doi: 10.5500/wjt.v16.i2.117138

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Figure 1 Recurrence of glomerular diseases. FSGS: Focal segmental glomerulosclerosis.

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Figure 2 Overlap between complement over activation and dysregulation. C3G: C3 glomerulopathy.

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Figure 3 Pathways of complement activation and inhibitors. MBL: Mannose-binding lectin; MASP: Mannose-binding lectin-associated serine protease; C5aR: C5a receptor.

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Figure 4 Alternate pathway: Activators and regulators. MCP: Membrane cofactor protein; DAF: Decay-accelerating factor.

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Figure 5 Treatment approach to C3 glomerulopathy. C3G: C3 glomerulopathy; RAAS: Renin-angiotensin-aldosterone system; MMF: Mycophenolate mofetil; ACTH: Adrenocorticotropic hormone.

Citation: Chutani A, Norouzi S, Lerma EV. C3 glomerulopathy in transplant “like yet unlike native”: Pathophysiology, recent advances in therapeutics and evolving paradigms. World J Transplant 2026; 16(2): 117138
URL: https://www.wjgnet.com/2220-3230/full/v16/i2/117138.htm
DOI: https://dx.doi.org/10.5500/wjt.v16.i2.117138

Chutani A, Norouzi S, Lerma EV. C3 glomerulopathy in transplant “like yet unlike native”: Pathophysiology, recent advances in therapeutics and evolving paradigms. World J Transplant 2026; 16(2): 117138 [DOI: 10.5500/wjt.v16.i2.117138]

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