Phosphoprotein phosphatase 1-interacting proteins as therapeutic targets in prostate cancer

doi:10.5497/wjp.v3.i4.120

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World J Pharmacol. Dec 9, 2014; 3(4): 120-139
Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.120

Table 1 Interactors of phosphoprotein phosphatase-1 expressed in human prostate tissue

PIP	Uniprot ID	Biological processes	PPP1 specificity	PPP1 binding motif
AKAP11	Q9UKA4	Intracellular signal transduction	PPP1CB, PPP1CC	RVxF, other motifs
APAF1	O14727	Apoptosis	PPP1CA	RVxF, other motifs
ATM	Q13315	Cell cycle; response to DNA damage; protein phosphorylation	PPP1CA	RVxF, SILK
AXIN1	O15169	Intracellular signal transduction; apoptosis; regulation of protein phosphorylation; transcription	PPP1CA	-
BAD¹	Q92934	Apoptosis	PPP1CA	other motifs
BCL2¹	P10415	Apoptosis; response to DNA damage; transmembrane transport	PPP1CA, PPP1CB	RVxF, other motifs
BCL2L2	Q92843	Apoptosis	PPP1CA	RVxF, other motifs
BRCA1	P38398	Cell cycle; DNA repair; lipid metabolism	PPP1CA, PPP1CB, PPP1CC	RVxF, other motifs
CCND1¹	P24385	Cell cycle; response to DNA damage; transcription	PPP1CB	-
CCND3	P30281	Cell cycle; intracellular signal transduction; protein phosphorylation	PPP1CB	-
CDC5L	Q99459	Cell cycle; transcription; mRNA splicing	PPP1CA	RVxF
CDC34	P49427	Cell cycle; protein ubiquitination; intracellular signal transduction	PPP1CB	other motifs
CDK2	P24941	Cell cycle; DNA repair; meiosis; mitosis; intracellular signal transduction; cell proliferation	PPP1CA	-
CDK4	P11802	Cell cycle; protein phosphorylation; cell proliferation	PPP1CA	-
CSRNP2	Q9H175	Apoptosis; transcription; protein phosphorylation	PPP1CA	RVxF, SILK
CUEDC2¹	Q9H467	Intracellular signal transduction	PPP1CA	-
CUL1	Q13616	Host-virus interaction; intracellular signal transduction	PPP1CA	-
EED	O75530	Transcription	PPP1CA	RVxF
EIF2AK2	P19525	Transcription; immunity; host-virus interaction	PPP1CA	other motifs
GABARAP	O95166	Apoptosis; autophagy; transport	PPP1CC	other motifs
GABARAPL2¹	P60520	Autophagy; transport	PPP1CC	-
GRB2	P62993	Host-virus interaction	PPP1CB	RVxF
GSK3B	P49841	Carbohydrate metabolism; differentiation; intracellular signal transduction	PPP1CA	-
HCFC1¹	P51610	Cell cycle; host-virus interaction	PPP1CA	RVxF, RARA
HDAC1¹	Q13547	Transcription; host-virus interaction; biological rhythms	PPP1CC	RVxF
HDAC6	Q9UBN7	Transcription; autophagy	PPP1CC	RVxF
HDAC8	Q9BY41	Transcription	PPP1CC	-
HDAC10¹	Q969S8	Transcription	PPP1CC	-
HEYL¹	Q9NQ87	Transcription; intracellular signal transduction	PPP1CA	RVxF
HSPA8	P11142	Host-virus interaction; mRNA processing; transcription	PPP1CA	other motifs
IKBKB¹	O14920	Intracellular signal transduction	PPP1CA	other motifs
IKBKG	Q9Y6K9	Transcription; host-virus interaction	PPP1CB, PPP1CC	RARA
LMTK2¹	Q8IWU2	Protein phosphorylation; intracellular transport; receptor recycling	PPP1CA	RVxF, other motifs
MAP1LC3A	Q9H492	Autophagy; intracellular signal transduction	PPP1CC	other motifs
MAP1LC3B¹	Q9GZQ8	Autophagy; intracellular signal transduction	PPP1CC	-
MAP3K3	Q99759	Intracellular signal transduction; protein phosphorylation	PPP1CA, PPP1CC	RVxF
MAX	P61244	Transcription	PPP1CA, PPP1CB	-
MDM4	O15151	Cell cycle; cell proliferation; apoptosis; response to DNA damage and hypoxia; protein stabilization; protein complex assembly	PPP1CA, PPP1CB, PPP1CC	-
MPHOSPH10	O00566	Ribosome biogenesis; RNA processing	PPP1CA	RVxF
MYC¹	P01106	Transcription	PPP1CA	RVxF
NCL	P19338	Transcription; angiogenesis	PPP1CB	other motifs
NCOR1	O75376	Transcription	PPP1CA, PPP1CB, PPP1CC	RVxF, other motifs
NOC2L	Q9Y3T9	Apoptosis; transcription	PPP1CA	RVxF
NOM1¹	Q5C9Z4	Targets PPP1CA to the nucleolus	PPP1CA	RVxF, SILK
PAK6	Q9NQU5	Transcription; protein phosphorylation; cytoskeleton organization; apoptosis	-	Other motifs
PLCL2	Q9UPR0	Intracellular signal transduction; lipid metabolic process	PPP1CA	RVxF
PPP1R2	P41236	Regulation of phosphoprotein phosphatase activity; regulation of signal transduction; carbohydrate and glycogen metabolism	PPP1CB, PPP1CC	SILK, other motifs
PPP1R3B	Q86XI6	Carbohydrate and glycogen metabolism	PPP1CA	RVxF
PPP1R3D¹	O95685	Regulation of protein dephosphorylation; carbohydrate and glycogen metabolism	PPP1CC	RVxF
PPP1R7¹	Q15435	Regulation of protein dephosphorylation; regulation of catalytic activity	PPP1CB	other motifs
PPP1R10	Q96QC0	Regulation of catalytic activity; transcription; protein import into nucleus	PPP1CA	RVxF
PPP1R11¹	O60927	Regulation of catalytic activity	PPP1CB	RVxF
PPP1R12A	O14974	Regulation of catalytic activity; intracellular transport; cell cycle; regulation of cell adhesion; protein dephosphorylation; intracellular signal transduction	PPP1CB	RVxF, MyPhoNE
PPP1R13B¹	Q96KQ4	Cell cycle; apoptosis	PPP1CA	RVxF
PPP1R14B	Q96C90	Regulation of phosphorylation; regulation of catalytic activity	PPP1CC	RVxF
PPP1R15A	O75807	Apoptosis; regulation of translation; stress response	PPP1CA, PPP1CB, PPP1CC	RVxF, RARA
PPP1R15B	Q5SWA1	Regulation of translation; stress response; dephosphorylation	PPP1CA	RVxF, other motifs
PPP1R26	Q5T8A7	Regulation of phosphatase activity	PPP1CA	RVxF
PPP1R37¹	O75864	Regulation of phosphatase activity	PPP1CA	RVxF
PTEN	P60484	Lipid metabolism; apoptosis; neurogenesis	PPP1CA	RVxF
PTK2	Q05397	Angiogenesis	PPP1CB	SILK
RB1¹	P06400	Transcription; cell cycle; host-virus interaction	PPP1CA	RVxF, SILK, other motifs
RIPK3	Q9Y572	Necrosis	PPP1CB, PPP1CC	RVxF
RPAP2	Q8IXW5	Transcription	PPP1CA	RVxF
RPAP3	Q9H6T3	Alternative splicing; polymorphism	PPP1CA	other motifs
RRP1B¹	Q14684	Regulation of phosphatase activity; RNA processing	PPP1CA	RVxF, other motifs
RUVBL2	Q9Y230	DNA repair; growth regulation; transcription	PPP1CA	-
RYR21	Q92736	Intracellular transport	PPP1CA, PPP1CB, PPP1CC	RVxF, other motifs
SF3A2	Q15428	mRNA processing and splicing	PPP1CA	-
SH2D4A¹	Q9H788	Regulation of phosphatase activity	PPP1CB	RVxF, MyPhoNE
SKP1	P63208	Intracellular signal transduction	PPP1CA	RVxF
SMARCB1	Q12824	Transcription; cell cycle; host-virus interaction; neurogenesis	PPP1CA, PPP1CB, PPP1CC	RVxF
SPRED1	Q7Z699	Regulation of protein phosphorylation; regulation of protein deacetylation; response to DNA damage; development	PPP1CA	RVxF
STAM¹	Q92783	Protein transport	PPP1CA	RVxF
STAU1¹	O95793	Intracellular mRNA localization	PPP1CA	RVxF, other motifs
SYTL2¹	Q9HCH5	Intracellular transport; exocytosis; regulation of phosphatase activity	PPP1CA	RVxF, SILK, other motifs
TMEM33	P57088	-	PPP1CB	-
TP53	P04637	Apoptosis; cell cycle; host-virus interaction; necrosis; transcription	PPP1CA	-
TP53BP2	Q13625	Intracellular signal transduction; apoptosis; cell cycle; embryo development; heart development; response to ionizing radiation	PPP1CA, PPP1CC	RVxF, other motifs
TRIM28¹	Q13263	Transcription; DNA repair; protein ubiquitination; protein sumoylation; protein oligomerization; gene expression; epithelial to mesenchymal transition; innate immune response; regulation of viral release from host cell	PPP1CA, PPP1CB, PPP1CC	RVxF
TUSC3	Q13454	Intracellular transport	PPP1CA	RVxF, other motifs
USF1	P22415	Transcription	PPP1CC	RVxF, other motifs
ZFYVE9¹	O95405	Intracellular signal transduction	PPP1CA, PPP1CB, PPP1CC	RVxF, other motifs
ZFYVE16	Q7Z3T8	Intracellular signal transduction; regulation of endocytosis; protein targeting	PPP1CA	RVxF, other motifs

¹Highly expressed in human prostate (criteria selection: prostate mRNA expression higher than the mean mRNA expression taking into account all tissues analyzed). Other motifs include apoptotic signature motifs and inhibitor-2 degenerate motif. PPP1: Phosphoprotein phosphatase-1; ATM: Ataxia telangiectasia mutated; GSK3B: Glycogen synthase kinase-3 β; SMARCB1: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; BRCA1: Breast cancer type 1 susceptibility protein.

Citation: Felgueiras J, Fardilha M. Phosphoprotein phosphatase 1-interacting proteins as therapeutic targets in prostate cancer. World J Pharmacol 2014; 3(4): 120-139
URL: https://www.wjgnet.com/2220-3192/full/v3/i4/120.htm
DOI: https://dx.doi.org/10.5497/wjp.v3.i4.120