Liver biopsy for visceral leishmaniasis diagnosis in pregnancy: report of 2 cases

Table 1 Biochemical test profile, blood and coagulation tests of the 1^st case

	Post-partum (d)
	19	24	29	32	Normal range
Biochemical test profile
GGT (U/L)	577	289	47	58	15-73
Alkaline Phosphatase (U/L)	1081	924	121	103	36-126
Aspartate transaminase (U/L)	338	3879	1212	429	30-110
Alanine transferase (U/L)	94	727	279	110	21-75
Albumin (g/dL)	2.3	2	1	1.5	3.5-5
INR	1.34	2.55	2.51	1.68	< 1.25
Total bilirubin (mg/dL)	13	15	10	16	0.2-1.3
Indirect bilirubin (mg/dL)	3	4	2	2	0-1.1
Direct bilirubin (mg/dL)	10	11	8	14	0-0.3
Blood and coagulation tests
Platelets (× 103/mm3)	155	132	55	22	140-440
Leukocytes (× 103/mm3)	7.3	5	2.5	0.9	4-11
Hemoglobin (g/dL)	10	9.7	4.4	10.5	12-16
Factor V (%)	-	70.2	40.7	64.8	50-150
Factor VII (%)	-	43.5	36	35.2	50-150
Fibrinogen (mg/dL)	-	164	90	193	146-380

GGT: Gamma-glutamyl transpeptidase; INR: International normalized ratio.

Table 2 Main laboratory tests of the 2^nd case during LV treatment

	Gestational week
	12	13	14	22	Normal range
GGT (U/L)	102	94	83	9	15-73
Alkaline Phosphatase (U/L)	116	106	109	45	36-126
Aspartate transaminase (U/L)	1711	2041	1905	16	30-110
Alanine transferase (U/L)	2198	2237	1809	15	21-75
Albumin (g/dL)	3.3	3.4	3.5	-	3.5-5
INR	1.29	1.51	1.69	1.2	< 1.25
Total bilirubin (mg/dL)	14.5	19.6	24.6	0.6	0.2-1.3
Indirect bilirubin (mg/dL)	1.6	2	2.4	0.4	0-1.1
Direct bilirubin (mg/dL)	10.7	15	16.3	0	0-0.3

GGT: Gamma-glutamyl transpeptidase; INR: International normalized ratio. LV treatment was initiated at the 12^th gestational week.