Copyright
©The Author(s) 2023.
World J Clin Infect Dis. Feb 28, 2023; 13(1): 1-10
Published online Feb 28, 2023. doi: 10.5495/wjcid.v13.i1.1
Published online Feb 28, 2023. doi: 10.5495/wjcid.v13.i1.1
Table 1 Selected templates for comparative modeling
| Antigen | Template (PDB) | Organism | Identity (%) | X-ray resolution (Å) | GMQE |
| ML2038 | 3UOI | M. tuberculosis | 90.51 | 1.90 | 0.96 |
| ML0050 | 3FAV | M. tuberculosis | 40.00 | 2.15 | 0.74 |
| ML0286 | 3EKL | M. tuberculosis | 87.46 | 1.51 | 0.96 |
| 85B Aga | 1F0N | M. tuberculosis | 85.21 | 1.80 | 0.81 |
Table 2 Validation of three-dimensional models of the Mycobacterium leprae antigens
| Antigen | Identification | Functional structure | MolProbity Score | Ramachandran plota (%) | Outliers (%) |
| ML2038 | Bacterioferritin | Homopolymer | 1.31 | 98.48 | 0.08 |
| ML0050 | ESAT-6-like protein esxB | Monomer | 0.77 | 98.61 | 0.00 |
| ML0286 | Fructose-bisphosphate aldolase | Homotetramer | 1.32 | 96.47 | 0.59 |
| 85B Ag | 85B antigen | Monomer | 1.85 | 93.95 | 0.00 |
- Citation: Melo de Assis BL, Viana Vieira R, Rudenco Gomes Palma IT, Bertolini Coutinho M, de Moura J, Peiter GC, Teixeira KN. Three-dimensional models of antigens with serodiagnostic potential for leprosy: An in silico study. World J Clin Infect Dis 2023; 13(1): 1-10
- URL: https://www.wjgnet.com/2220-3176/full/v13/i1/1.htm
- DOI: https://dx.doi.org/10.5495/wjcid.v13.i1.1