Observational Study
Copyright ©The Author(s) 2025.
World J Exp Med. Mar 20, 2025; 15(1): 96988
Published online Mar 20, 2025. doi: 10.5493/wjem.v15.i1.96988
Table 1 Sample characteristics, n (%)/mean ± SD/ median (minimum-maximum)
Variables
Total (n = 208)
Stage I (n = 25)
Stage II (n = 51)
Stage III + IV (n = 132)
P value
Demographics
Age (years) (n = 208)48.5 ± 10.2544.8 ± 9.0849.52 ± 10.8048.80 ± 10.150.14a
> 40 tahun41 (19.6)18 (72.00)40 (78.4)109 (82.6)0.44c
18-40 tahun167 (79.9)7 (28.00)11 (21.60)23 (17.4)
Marital status (n = 203)0.41c
Married200 (98.5)24 (100)51 (100)125 (97.7)
Not married3 (1.5)003 (2.3)
Parity history (n = 199)0.34c
Multiparity and grand multiparity175 (87.90)23 (95.8)42 (84.00)110 (88.00)
Nulliparity dan primiparity24 (12.10)1 (4.2)8 (16.00)15 (12.00)
Hormonal contraception use (n = 173)0.39c
Yes5 (2.90)1 (4.3)04 (3.8)
No168 (97.10)22 (95.7)46 (100)168 (97.10)
Histolopathological classification
Histopathological findings (n = 175)0.33c
Squamous cell carcinoma120 (68.60)13 (59.10)28 (63.60)79 (72.5)
Adenocarcinoma, mixed, and other55 (31.40)9 (40.9)16 (36.4)30 (27.5)
Laboratory examinations
Haemoglobin (g/L) (n = 204)102.5 ± 24.7124.6 ± 11.4109.3 ± 21.295.4 ± 24.6< 0.001a
Leucocyte (× 109/L) (n = 204)9.85 (4.05-29.60)7.47 (5.15-13.56)8.84 (4.32-22.34)11.08 (4.05-29.60)< 0.001b
Neutrophil (× 109/L) (n = 186)6.50 (1.52-25.16)4.78 (2.66-8.90)5.69 (3.14-17.20)7.43 (1.52-25.16)< 0.001b
Monocyte (× 109/L) (n = 186)0.65 (0.18-2.10)0.55 (0.33-1.22)0.53 (0.18-1.55)0.69 (0.27-2.10)0.002b
Lymphocyte (× 109/L) (n = 186)2.19 ± 2.152.18 ± 0.562.47 ± 0.722.09 ± 0.760.006a
Thrombocyte (× 109/L) (Neutrophil (× 109/L) (n = 186)375.5 (99-1143)307.00 (99.00-446.00)364.00 (131.00-1143.00)397.00 (147.00-791.00)< 0.001b
Neutrophil lymphocyte ratio (n = 186)3.13 (0.60-31.33)2.37 (0.96-4.22)2.31 (1.02-7.55)3.78 (0.60-31.33)< 0.001b
Lymphocyte monocyte ratio (n = 186)3.29 (0.67-13.50)3.77 ± 0.944.21 (1.86-13.50)3.00 (0.67-8.25)< 0.001b
Platelet lymphocyte ratio (n = 186)176.01 (63.82-779.08)141.03 (77.67-232.27)138.96 (70.91-561.12)200.49 (63.82-779.08)< 0.001b
Systematic inflammation index (n = 186)1195.47 (160.20-12282.67)719.00 ± 309.591159.36 (308.71-5715.00)1609.14 (160.20-12282.67)< 0.001b
Systematic inflammatory response index (n = 186)1.99 (0.25-16.54)1.51 ± 0.801.17 (0.40-6.88)2.96 (0.25-16.54)< 0.001b