Clinical and Translational Research
Copyright ©The Author(s) 2024.
World J Exp Med. Sep 20, 2024; 14(3): 93869
Published online Sep 20, 2024. doi: 10.5493/wjem.v14.i3.93869
Table 1 Demographic and clinicopathologic characteristics of United States patients diagnosed with anaplastic thyroid cancer between 2010 and 2017
Characteristics
n
Percent
Gender
Female36658.84
Male25641.16
Age at diagnosis, year old
00-5912820.58
60-7934254.98
80 + 15224.44
Marital status
Married34455.31
Single10216.40
Divorced/separated426.75
Widowed13421.54
Tumor stage
Localized345.47
Regional by direct extension only477.56
Regional lymph nodes involved only254.02
Regional by both direct extension and lymph node involvement538.52
Distant46374.44
Race
Non-Hispanic white38061.09
Non-Hispanic black477.56
Hispanic11218.01
Other8313.34
Living area
Counties in metropolitan areas of 1 million persons36558.68
Counties in metropolitan areas of 250000 to 1 million persons15124.28
Counties in metropolitan areas of 250000 persons325.14
Nonmetropolitan counties adjacent to a metropolitan area416.59
Nonmetropolitan counties not adjacent to a metropolitan area335.31
Income per year
$ < $45000294.66
$45000-549996911.09
$55000-6499912720.42
$65000-7499917427.97
$75000 + 22335.85
Radiation
No26742.93
Yes35557.07
Chemotherapy
No34355.14
Yes27944.86
Surgery
No35156.43
Yes27143.57
Year of diagnosis
20107512.06
20116710.77
20126410.29
20136810.93
20147411.90
20157912.70
20169615.43
20179915.92
Table 2 Crude analysis of factors associated with all-cause mortality and cancer related mortality among United States patients diagnosed with anaplastic thyroid cancer between 2010 and 2017
CharacteristicsOverall mortality
Cancer related mortality
Crude proportional, HR (95%CI)
Crude proportional, HR (95%CI)
Gender
Female1 (Reference)1 (Reference)
Male0.97 (0.80-1.16)0.96 (0.89-1.16)
Age at diagnosis, year old
00-591 (Reference)1 (Reference)
60-791.38 (1.10-1.74)b1.29 (1.02-1.64)a
80 + 1.64 (1.24-2.16)b1.16 (1.19-2.08)b
Marital status
Married1 (Reference)1 (Reference)
Single1.00 (0.77-1.30)0.94 (0.71-1.23)
Divorced/separated0.77 (0.54-1.11)0.76 (0.52-1.11)
Widowed1.23 (0.97-1.56)1.22 (0.96-1.55)
Tumor stage
Localized1 (Reference)1 (Reference)
Regional by direct extension only2.12 (1.22-3.66)b2.07 (1.16-3.66)a
Regional lymph nodes involved only1.58 (0.81-3.09)1.59 (0.79-3.20)
Regional by both direct extension and lymph node involvement1.75 (1.02-3.00)a1.82 (1.04-3.19)a
Distant3.24 (2.05-5.12)b3.25 (2.01-5.24)b
Race
Non-Hispanic white1 (Reference)1 (Reference)
Non-Hispanic black1.12 (0.79-1.59)1.11 (0.78-1.59)
Hispanic1.23 (0.96-1.58)1.22 (0.94-1.57)
Other1.30 (0.98-1.71)1.27 (0.95-1.69)
Living area
Counties in metropolitan areas of 1 million persons1 (Reference)1 (Reference)
Counties in metropolitan areas of 250000 to 1 million persons1.11 (0.89-1.38)1.11 (0.89-1.39)
Counties in metropolitan areas of 250000 persons0.74 (0.46-1.18)0.77 (0.47-1.24)
Nonmetropolitan counties adjacent to a metropolitan area0.80 (0.55-1.14)0.80 (0.55-1.16)
Nonmetropolitan counties not adjacent to a metropolitan area1.41 (0.93-2.15)1.49 (0.98-2.27)
Income per year
$ < $450001 (Reference)1 (Reference)
$45000-549990.92 (0.55-1.54)0.86 (0.51-1.45)
$55000-649991.35 (0.85-2.17)1.28 (0.80-2.06)
$65000-749991.01 (0.64-1.60)0.96 (0.60-1.52)
$75000 + 0.90 (0.57-1.43)0.85 (0.54-1.34)
Radiation
No1 (Reference)1 (Reference)
Yes0.61 (0.50-0.74)b0.59 (0.49-0.72)b
Chemotherapy
No1 (Reference)1 (Reference)
Yes0.61(0.50-0.73)b0.60(0.49-0.72)b
Surgery
No1 (Reference)1 (Reference)
Yes0.50 (0.41-0.59)b0.47 (0.39-0.58)b
aP < 0.05.
bP < 0.01.
HR: Hazard ratio.
Table 3 Multivariate cox proportional hazard regression analyses of factors affecting all-cause mortality and cancer related mortality among United States patients diagnosed with anaplastic thyroid cancer between 2010 and 2017
Characteristics
Overall mortality
Cancer related mortality
Adjusted proportional, HR (95%CI)
Adjusted proportional, HR (95%CI)
Gender
Female1 (Reference)1 (Reference)
Male1.11 (0.89-1.38)1.09 (0.87-1.36)
Age at diagnosis, year old
00-591 (Reference)1 (Reference)
60-792.85 (0.61-13.43)2.16 (0.46-10.18)
80 + 2.01 (0.40-10.18)1.48 (0.29-7.60)
Marital status
Married1 (Reference)1 (Reference)
Single1.00 (0.75-1.34)0.94 (0.69-1.26)
Divorced/separated0.63 (0.42-0.94)a0.61 (0.40-0.92)a
Widowed1.03 (0.78-1.37)1.03 (0.77-1.37)
Tumor stage
Localized1 (Reference)1 (Reference)
Regional by direct extension only6.26 (1.29-30.42)a5.05 (1.05-24.19)a
Regional lymph nodes involved only2.71 (0.42-17.49)2.30 (0.36-14.68)
Regional by both direct extension and lymph node involvement3.58 (0.74-17.31)2.97 (0.62-14.15)
Distant5.73 (1.34-24.51)a4.57 (1.08-19.29)a
Race
Non-Hispanic white1 (Reference)1 (Reference)
Non-Hispanic black0.91 (0.62-1.35)0.90 (0.60-1.34)
Hispanic1.16 (0.90-1.51)1.13 (0.87-1.49)
Other1.14 (0.85-1.54)1.12 (0.83-1.52)
Living area
Counties in metropolitan areas of 1 million persons1 (Reference)1 (Reference)
Counties in metropolitan areas of 250000 to 1 million persons1.26 (0.99-1.60)1.26 (0.99-1.61)
Counties in metropolitan areas of 250000 persons0.76 (0.46-1.27)0.82 (0.49-1.38)
Nonmetropolitan counties adjacent to a metropolitan area0.79 (0.50-1.26)0.80 (0.50-1.29)
Nonmetropolitan counties not adjacent to a metropolitan area1.19 (0.70-2.01)1.25 (0.74-2.13)
Income per year
$ < $450001 (Reference)1 (Reference)
$45000-549990.75 (0.43-1.31)0.72 (0.41-1.26)
$55000-649991.04 (0.59-1.82)1.01 (0.57-1.77)
$65000-749990.85 (0.48-1.51)0.84 (0.47-1.50)
$75000 + 0.74 (0.42-1.33)0.71 (0.40-1.29)
Radiation
No1 (Reference)1 (Reference)
Yes0.66 (0.53-0.83)b0.64 (0.51-0.81)b
Chemotherapy
No1 (Reference)1 (Reference)
Yes0.63 (0.50-0.79)b0.62 (0.50-0.78)b
Surgery
No1 (Reference)1 (Reference)
Yes0.53 (0.43-0.66)b0.51 (0.41-0.63)b
aP < 0.05.
bP < 0.01.
HR: Hazard ratio.
Table 4 Multivariate cox proportional hazard regression analyses of factors affecting all-cause mortality and anaplastic thyroid cancer related mortality among United States patients between 2010 and 2017 taking into account the interaction between tumor stage and age
Tumor stage and age (stage & age)
OM
CSM
I & 00-5911
II & 00-5911
II & 60-790.28 (0.06-1.62)0.31 (0.05-1.85)
II & 80 + 0.32 (0.05-2.08)0.43 (0.06-2.79)
III & 00-5911
III & 60-790.43 (0.05-3.63)0.44 (0.05-3.89)
III & 80 + 0.70 (0.08-6.13)0.91 (0.10-8.07)
IV & 00-5911
IV & 60-790.53 (0.09-2.99)0.65 (0.11-3.65)
IV & 80 + 0.52 (0.07-3.90)0.70 (0.09-5.29)
V & 00-5911
V & 60-790.44 (0.09-2.09)0.54 (0.11-2.58)
V & 80 + 0.70 (0.13-3.66)0.87 (0.16-4.63)
CSM: Cancer specific mortality; OM: Overall mortality.
  • Citation: Bangolo AI, Auda A, Bukasa-Kakamba J, Bhakta N, Dey S, lilhori A, Reddy G, Alqinai B, Sidiqui A, Sekhon I, Khatiashvili B, Abbas I, Kunnel S, Jarri A, Martinez E, Daoud D, Gupta I, Gompa H, Pender S, Aljaberi D, Aljanaahi H, Kunnel SS, Xiao Y, Jung Y, Nagpaul S, Naz A, Mallela T, Maung PM, Khalaf IY, Kim S, Alrestom R, Gajera A, Alkealy H, Kansal D, Dhall S, Satheesha S, Weissman S, Fwelo P. Interaction between tumor stage and age on survival outcomes of patients with anaplastic thyroid cancer. World J Exp Med 2024; 14(3): 93869
  • URL: https://www.wjgnet.com/2220-315x/full/v14/i3/93869.htm
  • DOI: https://dx.doi.org/10.5493/wjem.v14.i3.93869