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©The Author(s) 2024.
World J Exp Med. Mar 20, 2024; 14(1): 86898
Published online Mar 20, 2024. doi: 10.5493/wjem.v14.i1.86898
Published online Mar 20, 2024. doi: 10.5493/wjem.v14.i1.86898
TNF-α | Secreted by macrophages, natural killer cells, and lymphocytes[13]. Crucial in formation and maintenance of granulomas[30] |
IL-1 | Produced by various cell types including macrophages, fibroblasts, and epithelial cells[13]. Stimulates fibroblast and keratinocyte growth and collagen synthesis by fibroblasts |
IL-6 | Secreted by various cell types including macrophages and adipocytes[13]. An important mediator of the acute phase response and regulator of glucose homeostasis in obesity |
IL-8 | Produced by various cell types including macrophages, epithelial cells, and endothelial cells[13]. Primarily recruits neutrophils and other granulocytes to sites of tissue injury |
MCP-1 | Also known as CCL2. Primarily secreted by monocytes, macrophages, and dendritic cells[13]. Attracts monocytes, memory T cells, and dendritic cells to sites of inflammation produced by either tissue injury or inflammation |
Animal model | Advantages | Disadvantages |
Hypertrophic wound model | Low cost | Hypertrophic scar different from human[27,29] |
Allows for production of hypertrophic scar[28,29] | Requires special device[28,29] | |
Labor intensive: Frequent care to maintain tension and device placement[31] | ||
Wound-induced hair follicle neogenesis (WIHN) model | Low cost | |
Regeneration following adult wounding with minimal recovery of hair follicles at the scar center[32,48] | High variability: Mouse strains, environmental conditions, age of mice, and wound size)[33] | |
Test therapeutics to activate regenerative wound healing[33] | May not translate to human injury[48] | |
Excisional wound model | Low cost | Labor intensive: Frequent dressing changes to maintain tension[35] |
Wound healing similar to human[35] | ||
Allows for fibroblast lineage tracing[49] |
- Citation: Cotterell A, Griffin M, Downer MA, Parker JB, Wan D, Longaker MT. Understanding wound healing in obesity. World J Exp Med 2024; 14(1): 86898
- URL: https://www.wjgnet.com/2220-315x/full/v14/i1/86898.htm
- DOI: https://dx.doi.org/10.5493/wjem.v14.i1.86898