Comparative evaluation of effect of injectable platelet-rich fibrin with collagen membrane compared with collagen membrane alone for gingival recession coverage

doi:10.5493/wjem.v12.i4.68

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World Journal of Experimental Medicine

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World J Exp Med. Jul 20, 2022; 12(4): 68-91
Published online Jul 20, 2022. doi: 10.5493/wjem.v12.i4.68

Table 1 Demographic characteristics and mean values of clinical parameters

Demographic characteristics		Test, mean ± SD	Control, mean ± SD
Sex
Male	7
Female	6
Age	36.7 ± 12.44
PI		0.625 ± 0.151	0.625 ± 0.154
GI		0.625 ± 0.164	0.625 ± 0.65
PD		1.75 ± 0.444	2.05 ± 0.6
RD		2.7 ± 0.86	2.9 ± 0.71
RW		3.5 ± 0.6	3.7 ± 0.73
RAL		7.3 ± 0.8	7.05 ± 0.82
KTW		1.6 ± 0.5	1.35 ± 0.48
KTT		1.64 ± 0.237	1.61 ± 0.201

GI: Gingival index; KTT: Keratinised tissue thickness; KTW: Keratinised tissue width; PD: Pocket depth; PI: Plaque index; RAL: Relative attachment level; RD: Recession depth; RW: Recession width.

Table 2 Intergroup comparison of mean plaque scores between injectable platelet-rich fibrin + collagen membrane and collagen membrane at different time intervals using unpaired t test

Time (mo)	Group	n	mean ± SD		P value
0	i-PRF + CM	20	0.625	0.15174	1.000
	CM	20	0.625	0.15174	NS
1	i-PRF + CM	20	0.865	0.13485	0.544
	CM	20	0.835	0.17252	NS
3	i-PRF + CM	20	0.6	0.13377	0.211
	CM	20	0.545	0.13945	NS
6	i-PRF + CM	20	0.54	0.12732	0.810
	CM	20	0.53	0.13416	NS

Level of significance at P < 0.05. CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin; NS: Not significant using unpaired t test.

Table 3 Intragroup comparison of mean plaque scores obtained by using injectable platelet-rich fibrin + collagen membrane and collagen membrane at different time intervals

i-PRF + CM in mo	mean ± SD	P value	CM in mo	mean ± SD	P value
0	0.625 ± 0.151	0.001^a	0	0.625 ± 0.154	0.001^a
1	0.865 ± 0.134		1	0.835 ± 0.172
0	0.625 ± 0.151	0.204	0	0.625 ± 0.154	0.001^a
3	0.6 ± 0.133		3	0.545 ± 0.139
0	0.625 ± 0.151	0.001^a	0	0.625 ± 0.154	0.001^a
6	0.54 ± 0.127		6	0.53 ± 0.134
1	0.865 ± 0.134	0.001^a	1	0.835 ± 0.172	0.001^a
3	0.6 ± 0.133		3	0.545 ± 0.139
1	0.865 ± 0.134	0.001^a	1	0.835 ± 0.172	0.001^a
6	0.54 ± 0.127		6	0.56 ± 0.134
3	0.6 ± 0.133	0.004^a	3	0.545 ± 0.139	0.379
6	0.54 ± 0.127		6	0.56 ± 0.134

^aP < 0.01 statistically significant using paired t test.

Level of significance at P < 0.05. CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin.

Table 4 Intergroup comparison of mean gingival index scores between injectable platelet-rich fibrin + collagen membrane and collagen membrane at different time intervals using unpaired t test

mo	Group	n	mean ± SD	P value
0	i-PRF + CM	20	0.625 ± 0.16504	1.0
	CM	20	0.625 ± 0.16504	NS
1	i-PRF + CM	20	0.89 ± 0.14105	1.0
	CM	20	0.89 ± 0.18035	NS
3	i-PRF + CM	20	0.545 ± 0.1191	0.497
	CM	20	0.575 ± 0.15517	NS
6	i-PRF + CM	20	0.515 ± 0.14965	0.913
	CM	20	0.51 ± 0.13727	NS

Level of significance at P < 0.05. CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin; n: Number of frequency; NS: Not significant.

Table 5 Intragroup comparison of mean gingival index scores obtained by using injectable platelet-rich fibrin + collagen membrane and collagen membrane at different time intervals using paired t test

i-PRF + CM in mo	mean ± SD	P value	CM in mo	mean ± SD	P value
0	0.625 ± 0.164	0.001^a	0	0.625 ± 0.165	0.001^a
1	0.89 ± 0.141		1	0.89 ± 0.18
0	0.625 ± 0.164	0.001^a	0	0.625 ± 0.165	0.001^a
3	0.545 ± 0.119		3	0.575 ± 0.155
0	0.625 ± 0.164	0.001^a	0	0.625 ± 0.165	0.001^a
6	0.51 ± 0.149		6	0.51 ± 0.137
1	0.89 ± 0.141	0.001^a	1	0.89 ± 0.18	0.001^a
3	0.545 ± 0.119		3	0.575 ± 0.155
1	0.89 ± 0.141	0.001^a	1	0.89 ± 0.18	0.001^a
6	0.51 ± 0.149		6	0.51 ± 0.137
3	0.545 ± 0.119	0.137	3	0.545 ± 0.155	0.137
6	0.51 ± 0.149		6	0.51 ± 0.137

^aP < 0.01 statistically significant.

Level of significance at P < 0.05. CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin.

Table 6 Intergroup comparison of mean pocket depth scores between injectable platelet-rich fibrin + collagen membrane and collagen membrane at different time intervals using unpaired t test

Time (mo)	Group	n	mean ± SD	P value
0	i-PRF + CM	20	1.75 ± 0.44426	0.082
	CM	20	2.05 ± 0.60481	NS
1	i-PRF + CM	20	2.65 ± 0.48936	0.492
	CM	20	2.8 ± 0.83351	NS
3	i-PRF + CM	20	2.05 ± 0.22361	0.560
	CM	20	2.1 ± 0.30779	NS
6	i-PRF + CM	20	1.75 ± 0.44426	0.080
	CM	20	1.95 ± 0.22361	NS

Level of significance at P < 0.05. CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin; n: Number of frequency; NS: Not significant.

Table 7 Intragroup comparison of mean pocket depth scores obtained by using injectable platelet-rich fibrin + collagen membrane and collagen membrane at different time intervals using paired t test

i-PRF + CM in mo	mean ± SD	P value	CM in mo	mean ± SD	P value
0	1.75 ± 0.444	0.001^a	0	2.05 ± 0.6	0.001^a
1	2.65 ± 0.489		1	2.8 ± 0.83
0	1.775 ± 0.444	0.01^a	0	2.05 ± 0.6	0.002^a
3	2.05 ± 0.223		3	2.1 ± 0.3
0	1.75 ± 0.444	1.0	0	2.05 ± 0.6	0.08
6	1.75 ± 0.444		6	1.95 ± 0.223
1	2.65 ± 0.489	0.001^a	1	2.8 ± 0.83	0.748
3	2.05 ± 0.223		3	2.1 ± 0.6
1	2.65 ± 0.489	0.001^a	1	2.8 ± 0.83	0.428
6	1.75 ± 0.444		6	1.95 ± 0.223
3	2.45 ± 0.223	0.01^a	3	2.1 ± 0.3	0.001^a
6	1.75 ± 0.444		6	1.95 ± 0.223

^aP < 0.01 statistically significant.

Level of significance at P < 0.05. CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin.

Table 8 Intergroup comparison of mean recession depth scores between injectable platelet-rich fibrin + collagen membrane and collagen membrane at different time intervals using unpaired t test

Time (mo)	Group	n	mean ± SD	P value
0	i-PRF + CM	20	2.7 ± 0.865	0.431
	CM	20	2.9 ± 0.718	NS
1	i-PRF + CM	20	0.25 ± 0.444	0.108
	CM	20	0.5 ± 0.513	NS
3	i-PRF + CM	20	0.5 ± 0.513	0.008^a
	CM	20	0.95 ± 0.51
6	i-PRF + CM	20	0.9 ± 0.641	0.04^b
	CM	20	1.3 ± 0.571

^aP < 0.01 statistically significant.

^bP < 0.05 statistically significant.

CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin; NS: Not significant.

Table 9 Intragroup comparison of mean recession depth scores obtained by using injectable platelet-rich fibrin + collagen membrane and collagen membrane at different time intervals using paired t test

i-PRF + CM in mo	mean ± SD	P value	CM in mo	mean ± SD	P value
0	2.7 ± 0.86	0.001^a	0	2.9 ± 0.71	0.001^a
1	0.25 ± 0.4		1	0.5 ± 0.51
0	2.7 ± 0.86	0.001^a	0	2.9 ± 0.71	0.001^a
3	0.5 ± 0.5		3	0.95 ± 0.51
0	2.7 ± 0.86	0.001^a	0	2.9 ± 0.71	0.001^a
6	0.9 ± 0.64		6	1.3 ± 0.57
1	0.25 ± 0.4	0.021^b	1	0.5 ± 0.51	0.001^a
3	0.5 ± 0.5		3	0.95 ± 0.51
1	0.025 ± 0.4	0.001^a	1	0.5 ± 0.51	0.001^a
6	0.9 ± 0.64		6	1.3 ± 0.57
3	0.5 ± 0.5	0.002^a	3	0.95 ± 0.51	0.005^a
6	0.9 ± 0.64		6	1.3 ± 0.57

^aP < 0.01 statistically significant.

^bP < 0.05 statistically significant.

Level of significance at P < 0.05. CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin.

Table 10 Intergroup comparison of mean recession width scores between injectable platelet-rich fibrin + collagen membrane and collagen membrane at different time intervals using Mann-Whitney U test

Time (mo)	Group	n	mean ± SD		P value
0	i-PRF + CM	20	3.5	0.607	0.400
	CM	20	3.7	0.733	NS
1	i-PRF + CM	20	0.5	0.889	0.107
	CM	20	1	1.026	NS
3	i-PRF + CM	20	1	1.026	0.080
	CM	20	1.85	0.875
6	i-PRF + CM	20	1.65	1.04	0.001^a
	CM	20	2.55	0.759

^aP < 0.01 statistically significant.

Level of significance at ^aP < 0.05. CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin; NS: Not significant using Mann-Whitney U test.

Table 11 Intragroup comparison of mean recession width scores obtained by using injectable platelet-rich fibrin + collagen membrane and collagen membrane at different time intervals using Wilcoxon signed rank test

i-PRF + CM in mo	mean ± SD	P value	CM in mo	mean ± SD	P value
0	3.5 ± 0.6	0.001^a	0	3.7 ± 0.73	0.001^a
1	0.5 ± 0.8		1	1 ± 1.02
0	3.5 ± 0.6	0.001^a	0	3.7 ± 0.73	0.001^a
3	1 ± 1.02		3	1.85 ± 0.85
0	3.5 ± 0.6	0.001^a	0	3.7 ± 0.73	0.001^a
6	1.65 ± 1.03		6	2.55 ± 0.75
1	0.5 ± 0.8	0.025^b	1	1 ± 1.02	0.004^a
3	1 ± 1.02		3	1.85 ± 0.85
1	0.5 ± 0.8	0.001^a	1	1 ± 1.02	0.001^a
6	1.65 ± 1.03		6	2.55 ± 0.75
3	1 ± 1.02	0.009^a	3	1.85 ± 0.85	0.001^a
6	1.65 ± 1.03		6	2.55 ± 0.75

^aP < 0.01 statistically significant.

^bP < 0.05 statistically significant.

Level of significance at P < 0.05. CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin.

Table 12 Intergroup comparison of mean relative attachment level scores between injectable platelet-rich fibrin + collagen membrane at different time intervals using Mann-Whitney U test

Time (mo)	Group	n	mean ± SD	P value
0	i-PRF + CM	20	7.3 ± 0.801	0.429
	CM	20	7.05 ± 0.826	NS
1	i-PRF + CM	20	5.65 ± 1.348	0.620
	CM	20	5.4 ± 0.94	NS
3	i-PRF + CM	20	5.25 ± 1.293	0.779
	CM	20	5.05 ± 0.945	NS
6	i-PRF + CM	20	5.55 ± 1.099	0.779
	CM	20	5.45 ± 0.826	NS

Level of significance at P < 0.05. CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin; NS: Not significant using Mann-Whitney U test.

Table 13 Intragroup comparison of relative attachment level scores obtained by using injectable platelet-rich fibrin + collagen membrane and collagen membrane at different time intervals using Wilcoxon signed rank test

i-PRF + CM in mo	mean ± SD	P value	CM in mo	mean ± SD	P value
0	7.3 ± 0.8	0.001^a	0	7.05 ± 0.82	0.001^a
1	5.6 ± 1.3		1	5.4 ± 0.94
0	7.3 ± 0.8	0.001^a	0	7.05 ± 0.82	0.001^a
3	5.25 ± 1.29		3	5.05 ± 0.94
0	7.3 ± 0.8	0.001^a	0	7.05 ± 0.82	0.001^a
6	5.55 ± 1.09		6	5.45 ± 0.82
1	5.6 ± 1.3	0.021^b	1	5.4 ± 0.94	0.124
3	5.25 ± 1.29		3	5.05 ± 0.94
1	5.6 ± 1.3	0.589	1	5.4 ± 0.94	0.868
6	5.55 ± 1.06		6	5.45 ± 0.82
3	5.52 ± 1.29	0.06	3	5.05 ± 0.94	0.021^a
6	5.55 ± 1.06		6	5.45 ± 0.82

^aP < 0.01 statistically significant.

^bP < 0.05 statistically significant.

Level of significance at P < 0.05. CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin.

Table 14 Intergroup comparison of width of keratinized tissue between injectable platelet-rich fibrin + collagen membrane at different time intervals using Mann-Whitney U test

Time (mo)	Group	n	mean ± SD	P value
0	i-PRF + CM	20	1.6 ± 0.503	0.183
	CM	20	1.35 ± 0.489	NS
1	i-PRF + CM	20	2.85 ± 0.489	0.040^b
	CM	20	2.45 ± 0.605
3	i-PRF + CM	20	3.5 ± 0.513	0.004^a
	CM	20	2.9 ± 0.447
6	i-PRF + CM	20	3.4 ± 0.598	0.003^a
	CM	20	2.75 ± 0.444

^aP < 0.01 statistically significant.

^bP < 0.05 statistically significant.

Level of significance at P < 0.05. CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin; NS: Not significant.

Table 15 Intragroup comparison of width of keratinized tissue scores obtained by using injectable platelet-rich fibrin + collagen membrane and collagen membrane at different time intervals using Wilcoxon signed rank test

i-PRF + CM in mo	mean ± SD	P value	CM in mo	mean ± SD	P value
0	1.6 ± 0.5	0.001^a	0	1.35 ± 0.48	0.001^a
1	2.85 ± 0.48		1	2.45 ± 0.6
0	1.6 ± 0.5	0.001^a	0	1.35 ± 0.48	0.001^a
3	3.5 ± 0.51		3	2.9 ± 0.44
0	1.6 ± 0.5	0.001^a	0	1.35 ± 0.48	0.001^a
6	3.4 ± 0.59		6	2.75 ± 0.44
1	2.85 ± 0.48	0.001^a	1	2.45 ± 0.6	0.001^a
3	3.5 ± 0.51		3	2.9 ± 0.44
1	2.85 ± 0.48	0.001^a	1	2.45 ± 0.6	0.001^a
6	3.4 ± 0.59		6	2.75 ± 0.44
3	3.5 ± 0.51	0.001^a	3	2.9 ± 0.44	0.001^a
6	3.4 ± 0.59		6	2.75 ± 0.44

^aP < 0.01 statistically significant.

Level of significance at P < 0.05. CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin.

Table 16 Intergroup comparison of thickness of keratinized tissue scores between injectable platelet-rich fibrin + collagen membrane and collagen membrane at different time intervals using unpaired t test

Time (mo)	Group	n	mean ± SD	P value
0	i-PRF + CM	20	1.65 ± 0.238	0.685
	CM	20	1.62 ± 0.202	NS
1	i-PRF + CM	20	2.69 ± 0.233	0.001^a
	CM	20	2.12 ± 0.193
3	i-PRF + CM	20	2.53 ± 0.212	0.001^a
	CM	20	2.02 ± 0.18
6	i-PRF + CM	20	2.46 ± 0.252	0.001^a
	CM	20	1.91 ± 0.166

^aP < 0.01 statistically significant using unpaired t test.

Level of significance at P < 0.05; CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin; NS: Not significant.

Table 17 Intragroup comparison of thickness of keratinized tissue scores obtained by using injectable platelet-rich fibrin and collagen membrane at different time intervals using paired t test

i-PRF + CM in mo	mean ± SD	P value	CM in mo	mean ± SD	P value
0	1.64 ± 0.237	0.001^a	0	1.61 ± 0.201	0.001^a
1	2.68 ± 0.233		1	2.11 ± 0.193
0	1.64 ± 0.237	0.001^a	0	1.61 ± 0.201	0.001^a
3	2.52 ± 0.211		3	2.01 ± 0.179
0	1.64 ± 0.237	0.001^a	0	1.61 ± 0.201	0.001^a
6	2.45 ± 0.252		6	1.91 ± 0.166
1	2.68 ± 0.233	0.001^a	1	2.11 ± 0.193	0.001^a
3	2.52 ± 0.211		3	2.01 ± 0.179
1	2.68 ± 0.233	0.001^a	1	2.11 ± 0.193	0.001^a
6	2.45 ± 0.252		6	1.91 ± 0.166
3	2.52 ± 0.211	0.001^a	3	2.01 ± 0.179	0.001^a
6	2.45 ± 0.252		6	1.91 ± 0.166

^aP < 0.01 statistically significant.

Level of significance at P < 0.05. CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin.

Table 18 Overall percentage of root coverage in the 1^stmonth, 3^rdmonth and 6^thmonth in patients treated with injectable platelet-rich fibrin + collagen membrane and collagen membrane respectively

Group	Month 1	Month 3	Month 6
i-PRF + CM	91.6	81.6	67
CM	82.3	66.4	53.95

CM: Collagen membrane; i-PRF: Injectable platelet-rich fibrin.

Citation: Patra L, Raj SC, Katti N, Mohanty D, Pradhan SS, Tabassum S, Mishra AK, Patnaik K, Mahapatra A. Comparative evaluation of effect of injectable platelet-rich fibrin with collagen membrane compared with collagen membrane alone for gingival recession coverage. World J Exp Med 2022; 12(4): 68-91
URL: https://www.wjgnet.com/2220-315x/full/v12/i4/68.htm
DOI: https://dx.doi.org/10.5493/wjem.v12.i4.68