Odd couple: The unexpected partnership of glucocorticoid hormones and cysteinyl-leukotrienes in the extrinsic regulation of murine bone-marrow eosinopoiesis

Table 1 The spectrum of GC-dependent effects on bone-marrow eosinopoiesis

In vivo treatment	Bone-marrow effects						Systemic factors		Ref.
	In vivo bone-marrow Eosinophilia	Ex vivo effects on response to GM-CSF (CFU counts) in bone-marrow culture		Ex vivo effects of challenge on responses to IL-5 or CysLT in bone-marrow culture			GC measurements and interventions targeting GC
		Total	Eosinophil	Priming	Maturation of eosinophils in culture	Regulation of CysLT responses	Blockade by GC targeting	Plasma corticosterone
None	Baseline	NA	NA	NA	Complete	NA	No effect	Baseline	[36,52]
Dexamethasone (5-20 mg/kg)	Baseline (BALB/c)	Increase	Increase	Primed by 24 h of injection	Incomplete, rescued by PGE2, anti-α4 integrin antibody	NE	RU486	NA	[51,36]
	Increased (C57BL/6)	Increase	NE	NE	NE	NE	RU486	N. A.	[53]
Surgical trauma	Increased (BALB/c) by 24 h of trauma	NE	NE	Primed by 24 h of trauma	Complete	NE	RU486 Metirapone	Stress level by 24 h of trauma	[52]
Sensitization and challenge	Increased (BALB/c, B6, BP-2) by 24 h of challenge	No significant increase	Increased by 24 h of challenge	Primed by 24 h of challenge	Complete	Attenuated by 24 h of challenge	RU486 Metirapone (eosinophilia, priming)	Stress level by 24 h of challenge (BALB/c), TNF- induced	[22,25,45, 47,50,54,70]
Oral tolerance induction, sensitization and challenge	Increase prevented (BALB/c, BP-2) by 24 h of challenge	Increased by 24 h of challenge	Increased by 24 of challenge	Priming prevented (BP-2) by 24 h of challenge	Complete	NE	NA	NE	[48]

CFU: Colony-forming unit; NE: Not examined in the study; NA: Not applicable to the study.