Natural compounds as anticancer agents: Experimental evidence

Table 1 Selected ongoing clinical trials with natural anti-cancer compounds

Agent	Phase	Status	Trial type	Conditions/cancer type	Combinati-on	Trial No.
Curcumin	Phase II	Recruiting	Prevention	Familial adenomatous polyposis		NCT00641147
	Phase I	Completed	Prevention	Healthy		NCT00027495
	Phase I	Recruiting	Treatment	Advanced osteosarcoma		NCT00689195
	Phase II
	Phase II	Recruiting	Treatment	Advanced pancreatic cancer		NCT00094445
Tea polyphenols	Phase II	Recruiting	Prevention	Postmenopausal women with high breast density		NCT00917735
	Phase II	Recruiting	Prevention	Tobacco use disorder		NCT00611650
	Phase I	Recruiting	Prevention	Premalignant lesions of the head and neck	Erlotinib	NCT01116336
	Phase I	Recruiting	Treatment	Small cell lung carcinoma		NCT01317953
	Phase II	Recruiting	Treatment	Multiple myeloma and plasma cell neoplasm		NCT00942422
	Phase II	Completed	Treatment	Bladder cancer		NCT00088946
Indole-3-carbinol/3,3-diindolylmethane	Phase II	Completed	Prevention	Healthy men at risk for prostate cancer progression		NCT00579332
	Phase III
	Phase I	Recruiting	Prevention	Women with a BRCA1 mutation		NCT01022333
	Phase I	Completed	Treatment	Prostate cancer	Radical prostatectomy	NCT00450229
	Phase II
	Phase II	Recruiting	Treatment	Breast cancer		NCT01391689
	Phase III
Vitamin D		Completed	Observation of the relationship between vitamin D level and thyroid cancer	Thyroid cancer		NCT00719615
	Phase II	Recruiting	Prevention	Postmenopausal women at high risk for breast cancer		NCT00859651
	Phase III	Enrolling by invitation	Prevention	Adenomatous colon polyps	Calcium	NCT00399607
	Phase I	Recruiting	Treatment	Metastatic melanoma	Temozolomide	NCT00301067
	Phase II
	Phase II	Completed	Treatment	Metastatic or locally advanced pancreatic cancer	Docetaxel	NCT00238199
	Phase IV	Completed	Prevention of osteoporosis	Postmenopausal breast cancer survivors	Risedronate; calcium	NCT00567606

Data from the United States National Institutes of Health, http://www.clinicaltrials.gov/.