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For: Geisler A, Fechner H. MicroRNA-regulated viral vectors for gene therapy. World J Exp Med 2016; 6(2): 37-54 [PMID: 27226955 DOI: 10.5493/wjem.v6.i2.37]
URL: https://www.wjgnet.com/2220-315X/full/v6/i2/37.htm
Number Citing Articles
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Ben Mead, Stanislav Tomarev. The role of miRNA in retinal ganglion cell health and diseaseNeural Regeneration Research 2022; 17(3) doi: 10.4103/1673-5374.320974
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Neeti Vashi, Monica J. Justice. Treating Rett syndrome: from mouse models to human therapiesMammalian Genome 2019; 30(5-6) doi: 10.1007/s00335-019-09793-5
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Cornelia Braicu, Diana Gulei, Beatriz de Melo Maia, Ioana Berindan-Neagoe, George A. Calin. Genomic Applications in Pathology2019;  doi: 10.1007/978-3-319-96830-8_5
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ANSELM J. Gadenstaetter, LUKAS SCHMUTZLER, DIRK GRIMM, LUKAS D. LANDEGGER. Intranasal application of adeno-associated viruses: a systematic reviewTranslational Research 2022; 248 doi: 10.1016/j.trsl.2022.05.002
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Grit Taschenberger, Julia Tereshchenko, Sebastian Kügler. A MicroRNA124 Target Sequence Restores Astrocyte Specificity of gfaABC1D-Driven Transgene Expression in AAV-Mediated Gene TransferMolecular Therapy - Nucleic Acids 2017; 8 doi: 10.1016/j.omtn.2017.03.009
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Brian J. Parrett, Satoko Yamaoka, Michael A. Barry. Reducing off-target expression of mRNA therapeutics and vaccines in the liver with microRNA binding sitesMolecular Therapy Methods & Clinical Development 2025; 33(1) doi: 10.1016/j.omtm.2024.101402
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Shama Prasada Kabekkodu, Vaibhav Shukla, Vinay Koshy Varghese, Divya Adiga, Padacherri Vethil Jishnu, Sanjiban Chakrabarty, Kapaettu Satyamoorthy. Cluster miRNAs and cancer: Diagnostic, prognostic and therapeutic opportunitiesWIREs RNA 2020; 11(2) doi: 10.1002/wrna.1563
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Joana Silva, Paula A. da Costa Martins. Non-Coding RNAs in the Therapeutic Landscape of Pathological Cardiac HypertrophyCells 2022; 11(11) doi: 10.3390/cells11111805
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Yeganeh Rastgar Rezaei, Reza Zarezadeh, Saba Nikanfar, Hajar Oghbaei, Nahideh Nazdikbin, Zahra Bahrami-Asl, Nosratollah Zarghami, Yadollah Ahmadi, Amir Fattahi, Mohammad Nouri, Ralf Dittrich. microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentialsSystems Biology in Reproductive Medicine 2021; 67(5) doi: 10.1080/19396368.2021.1951890
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Samaneh Toutounchian, Naser Ahmadbeigi, Vahid Mansouri. Retinal and Choroidal Neovascularization Antivascular Endothelial Growth Factor Treatments: The Role of Gene TherapyJournal of Ocular Pharmacology and Therapeutics 2022; 38(8) doi: 10.1089/jop.2022.0022
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Ruchi Jain, Josh P. Frederick, Eric Y. Huang, Kristine E. Burke, David M. Mauger, Elizaveta A. Andrianova, Sam J. Farlow, Summar Siddiqui, Jeffrey Pimentel, Kahlin Cheung-Ong, Kristine M. McKinney, Caroline Köhrer, Melissa J. Moore, Tirtha Chakraborty. MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-DestructNucleic Acid Therapeutics 2018; 28(5) doi: 10.1089/nat.2018.0734
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Barsha Dassarma, Satyajit Tripathy. Non-Coding RNA Signatures in Breast and Pancreatic Cancer: from Molecular Drivers To Diagnostic ToolsCurrent Genetic Medicine Reports 2025; 13(1) doi: 10.1007/s40142-025-00234-1
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Chiara Borsotti, Ester Borroni, Antonia Follenzi. Lentiviral vector interactions with the host cellCurrent Opinion in Virology 2016; 21 doi: 10.1016/j.coviro.2016.08.016
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Jiang-Hui Wang, Damien Ling, Leilei Tu, Peter van Wijngaarden, Gregory J. Dusting, Guei-Sheung Liu. Gene therapy for diabetic retinopathy: Are we ready to make the leap from bench to bedside?Pharmacology & Therapeutics 2017; 173 doi: 10.1016/j.pharmthera.2017.01.003
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Thomas Böldicke. Therapeutic Potential of Intrabodies for Cancer Immunotherapy: Current Status and Future DirectionsAntibodies 2022; 11(3) doi: 10.3390/antib11030049
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T. V. Egorova, A. A. Piskunov, D. A. Poteryaev. Adeno-associated virus vector-based gene therapy for hereditary diseases: current problems of application and approaches to solve themBiological Products. Prevention, Diagnosis, Treatment 2024; 24(2) doi: 10.30895/2221-996X-2024-24-2-123-139
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Marc Oudart, Karen M. J. van Loo, Deborah Kronenberg-Versteeg. Live-cell physiology in human brain tissue culture—the potential, the challenges, and the lessons learnedFrontiers in Cellular Neuroscience 2026; 20 doi: 10.3389/fncel.2026.1777650
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Deepika Tuteja, Amit K. Yadav, Dhiraj Bhatia, Abhishek Kumar. microRNA Modulation: A Promising Combination Therapy for Cancer2026;  doi: 10.1007/978-981-95-5989-3_9
19
Sanae Bencheikh, Hajar Lemriss, Amal Souiri, Jihane Akachar, Khalid Laarej, Rabii Ameziane El Hassani, Sanaâ Lemriss. Human papillomavirus-encoded microRNAs: key regulators in cervical cancer developmentRNA Biology 2026; 23(1) doi: 10.1080/15476286.2026.2641715
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Prakriti Gaur, Naina Rajak, Aman Tiwari, Praveen Kumar, Neha Garg. MicroRNA in Human Infectious Diseases2024;  doi: 10.1016/B978-0-323-99661-7.00005-9
21
Ahmed S. Doghish, Elsayed G. E. Elsakka, Hebatallah Ahmed Mohamed Moustafa, Alaa Ashraf, Sherif S. Abdel Mageed, Osama A. Mohammed, Mustafa Ahmed Abdel-Reheim, Mohamed Bakr Zaki, Hanan Elimam, Nehal I. Rizk, Sarah A. Omran, Shimaa A. Farag, Donia G. Youssef, Ahmed I. Abulsoud. Harnessing the power of miRNAs for precision diagnosis and treatment of male infertilityNaunyn-Schmiedeberg's Archives of Pharmacology 2025; 398(4) doi: 10.1007/s00210-024-03594-7
22
Stefan Somplatzki, Martina Mühlenhoff, Andrea Kröger, Rita Gerardy-Schahn, Thomas Böldicke. Intrabodies against the Polysialyltransferases ST8SiaII and ST8SiaIV inhibit Polysialylation of NCAM in rhabdomyosarcoma tumor cellsBMC Biotechnology 2017; 17(1) doi: 10.1186/s12896-017-0360-7
23
Vassilios J Bezzerides, Maksymilian Prondzynski, Lucie Carrier, William T Pu. Gene therapy for inherited arrhythmiasCardiovascular Research 2020; 116(9) doi: 10.1093/cvr/cvaa107
24
Lukas P.M. Kremer, Santiago Cerrizuela, Sascha Dehler, Thomas Stiehl, Jonas Weinmann, Heike Abendroth, Susanne Kleber, Alexander Laure, Jihad El Andari, Simon Anders, Anna Marciniak-Czochra, Dirk Grimm, Ana Martin-Villalba. High throughput screening of novel AAV capsids identifies variants for transduction of adult NSCs within the subventricular zoneMolecular Therapy - Methods & Clinical Development 2021; 23 doi: 10.1016/j.omtm.2021.07.001
25
Lauren Major, Michelle E. McClements, Robert E. MacLaren. A Review of CRISPR Tools for Treating Usher Syndrome: Applicability, Safety, Efficiency, and In Vivo DeliveryInternational Journal of Molecular Sciences 2023; 24(8) doi: 10.3390/ijms24087603
26
Ulrich T. Hacker, Martin Bentler, Dorota Kaniowska, Michael Morgan, Hildegard Büning. Towards Clinical Implementation of Adeno-Associated Virus (AAV) Vectors for Cancer Gene Therapy: Current Status and Future PerspectivesCancers 2020; 12(7) doi: 10.3390/cancers12071889
27
Marianna K. Keaveney, Hua-an Tseng, Tina L. Ta, Howard J. Gritton, Heng-Ye Man, Xue Han. A MicroRNA-Based Gene-Targeting Tool for Virally Labeling Interneurons in the Rodent CortexCell Reports 2018; 24(2) doi: 10.1016/j.celrep.2018.06.049
28
Simone Merlin, Antonia Follenzi. Transcriptional Targeting and MicroRNA Regulation of Lentiviral VectorsMolecular Therapy - Methods & Clinical Development 2019; 12 doi: 10.1016/j.omtm.2018.12.013
29
Michael F. Naso, Brian Tomkowicz, William L. Perry, William R. Strohl. Adeno-Associated Virus (AAV) as a Vector for Gene TherapyBioDrugs 2017; 31(4) doi: 10.1007/s40259-017-0234-5
30
Jasdeep Kaur Dhanoa, Jasdeep Singh, Amarjit Singh, Jaspreet Singh Arora, R. S. Sethi, C. S. Mukhopadhyay. Discovery of isomiRs in PBMCs of diseased vis-à-vis healthy Indian water buffaloesExRNA 2019; 1(1) doi: 10.1186/s41544-019-0013-1
31
Ramya Rallabandi, Brenna Sharp, Conrad Cruz, Qi Wang, Alexis Locsin, Christopher B. Driscoll, Ella Lee, Tim Nelson, Patricia Devaux. miRNA-mediated control of exogenous OCT4 during mesenchymal-epithelial transition increases measles vector reprogramming efficiencyMolecular Therapy - Methods & Clinical Development 2022; 24 doi: 10.1016/j.omtm.2021.11.012
32
Giovanna Giacca, Mario Leonardo Squadrito. Targeting immune heterogeneity in liver metastases through in vivo genetic engineeringSeminars in Immunology 2026; 81 doi: 10.1016/j.smim.2025.102012
33
Juliette Hordeaux, Elizabeth L. Buza, Brianne Jeffrey, Chunjuan Song, Tahsin Jahan, Yuan Yuan, Yanqing Zhu, Peter Bell, Mingyao Li, Jessica A. Chichester, Roberto Calcedo, James M. Wilson. MicroRNA-mediated inhibition of transgene expression reduces dorsal root ganglion toxicity by AAV vectors in primatesScience Translational Medicine 2020; 12(569) doi: 10.1126/scitranslmed.aba9188
34
Khairunnisa’ Md Yusof, Kira Groen, Rozita Rosli, Kelly A. Avery-Kiejda. Crosstalk Between microRNAs and the Pathological Features of Secondary LymphedemaFrontiers in Cell and Developmental Biology 2021; 9 doi: 10.3389/fcell.2021.732415
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Marika Marino, Matthew G. Holt. AAV Vector-Mediated Antibody Delivery (A-MAD) in the Central Nervous SystemFrontiers in Neurology 2022; 13 doi: 10.3389/fneur.2022.870799
36
Ilya A. Volkhin, Anastasia Iu. Paremskaia, Maria A. Dashian, Darya S. Smeshnova, Roman E. Pavlov, Olga N. Mityaeva, Pavel Yu. Volchkov, Andrei A. Deviatkin. Selection of UTRs in mRNA-Based Gene Therapy and VaccinesBiochemistry (Moscow) 2025; 90(6) doi: 10.1134/S0006297924604659
37
Mohammad Shayestehpour, Sharareh Moghim, Vahid Salimi, Somayeh Jalilvand, Jila Yavarian, Bizhan Romani, Talat Mokhtari-Azad. Targeting human breast cancer cells by an oncolytic adenovirus using microRNA-targeting strategyVirus Research 2017; 240 doi: 10.1016/j.virusres.2017.08.016
38
Daniel Blessing, Nicole Déglon. Adeno-associated virus and lentivirus vectors: a refined toolkit for the central nervous systemCurrent Opinion in Virology 2016; 21 doi: 10.1016/j.coviro.2016.08.004
39
Marwa Ali Abdulnabi, Enass Abdul Kareem Dagher Al‑Saadi, Israa M. Al‑Bayaa. Gene therapy for hemophilia: Recent developments and challenges (Review)World Academy of Sciences Journal 2025; 7(3) doi: 10.3892/wasj.2025.329
40
Maxim Girod, Anja Geisler, Luisa Hinze, Leslie Elsner, Babette Dieringer, Antje Beling, Jens Kurreck, Henry Fechner. Combination of FOLFOXIRI Drugs with Oncolytic Coxsackie B3 Virus PD-H Synergistically Induces Oncolysis in the Refractory Colorectal Cancer Cell Line Colo320International Journal of Molecular Sciences 2024; 25(11) doi: 10.3390/ijms25115618
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Qingxuan Lai, Nikolai Kovzel, Ruslan Konovalov, Ilya A. Vinnikov. Autophagy: Biology and DiseasesAdvances in Experimental Medicine and Biology 2021; 1208 doi: 10.1007/978-981-16-2830-6_11
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Timothy Frei, Federica Cella, Fabiana Tedeschi, Joaquín Gutiérrez, Guy-Bart Stan, Mustafa Khammash, Velia Siciliano. Characterization and mitigation of gene expression burden in mammalian cellsNature Communications 2020; 11(1) doi: 10.1038/s41467-020-18392-x
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Bijay Dhungel, Charmaine A. Ramlogan-Steel, Jason C. Steel. MicroRNA-Regulated Gene Delivery Systems for Research and Therapeutic PurposesMolecules 2018; 23(7) doi: 10.3390/molecules23071500
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Manish Muhuri, Daniel I. Levy, Martin Schulz, Douglas McCarty, Guangping Gao. Durability of transgene expression after rAAV gene therapyMolecular Therapy 2022; 30(4) doi: 10.1016/j.ymthe.2022.03.004
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Barbara Bettegazzi, Stefano Cattaneo, Michele Simonato, Silvia Zucchini, Marie Soukupova. Viral Vector-Based Gene Therapy for Epilepsy: What Does the Future Hold?Molecular Diagnosis & Therapy 2024; 28(1) doi: 10.1007/s40291-023-00687-6
46
Ceri A. Pickering, Nicholas D. Mazarakis. Viral Vector Delivery of DREADDs for CNS TherapyCurrent Gene Therapy 2021; 21(3) doi: 10.2174/1566523221666210211102435
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Nicholas Donohue, Niamh Keogh, Stefano Boi, Niall Barron. Cell Culture Engineering and TechnologyCell Engineering 2021; 10 doi: 10.1007/978-3-030-79871-0_11
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Jiang-Hui Wang, Georgina Eloise Roberts, Guei-Sheung Liu. Updates on Gene Therapy for Diabetic RetinopathyCurrent Diabetes Reports 2020; 20(7) doi: 10.1007/s11892-020-01308-w
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Estera Rintz, Betul Celik, Nidhi Fnu, Angélica María Herreño-Pachón, Shaukat Khan, Eliana Benincore-Flórez, Shunji Tomatsu. Adeno-associated virus-based gene therapy delivering combinations of two growth-associated genes to MPS IVA miceMolecular Therapy - Nucleic Acids 2024; 35(2) doi: 10.1016/j.omtn.2024.102211
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Shadia Hamoud Alshahrani, Ameer A. Alameri, Fitriani Kahar, Andrés Alexis Ramírez-Coronel, Rasha Fadhel Obaid, Fahad Alsaikhan, Rahman S. Zabibah, Qutaiba A. Qasim, Farag M.A. Altalbawy, Yasser Fakri Mustafa, Rasoul Mirzaei, Sajad Karampoor. Overview of the role and action mechanism of microRNA-128 in viral infectionsMicrobial Pathogenesis 2023; 176 doi: 10.1016/j.micpath.2023.106020
51
Xinhong Chen, Damien A. Wolfe, Dhanesh Sivadasan Bindu, Mengying Zhang, Naz Taskin, David Goertsen, Timothy F. Shay, Erin E. Sullivan, Sheng-Fu Huang, Sripriya Ravindra Kumar, Cynthia M. Arokiaraj, Viktor M. Plattner, Lillian J. Campos, John K. Mich, Deja Monet, Victoria Ngo, Xiaozhe Ding, Victoria Omstead, Natalie Weed, Yeme Bishaw, Bryan B. Gore, Ed S. Lein, Athena Akrami, Cory Miller, Boaz P. Levi, Annika Keller, Jonathan T. Ting, Andrew S. Fox, Cagla Eroglu, Viviana Gradinaru. Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primatesNature Communications 2023; 14(1) doi: 10.1038/s41467-023-38582-7
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Audrey Choi, Michael O’Leary, Yuman Fong, Nanhai Chen. From Benchtop to Bedside: A Review of Oncolytic VirotherapyBiomedicines 2016; 4(3) doi: 10.3390/biomedicines4030018
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Pedram Moeini, Gloria González-Aseguinolaza. BiotherapeuticsTopics in Medicinal Chemistry 2024; 42 doi: 10.1007/7355_2024_173
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Andrew Walayat, Meizi Yang, DaLiao Xiao. Antisense Therapy2019;  doi: 10.5772/intechopen.82738
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Ki Jeong Lee, Yang Li. Utilities of AAV vectors in in vivo phenotypic screening and functional studiesExpert Opinion on Therapeutic Targets 2017; 21(4) doi: 10.1080/14728222.2017.1292442
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C Alexandri, A Daniel, G Bruylants, I Demeestere. The role of microRNAs in ovarian function and the transition toward novel therapeutic strategies in fertility preservation: from bench to future clinical applicationHuman Reproduction Update 2020; 26(2) doi: 10.1093/humupd/dmz039
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Edward M. Kennedy, Terry Farkaly, Peter Grzesik, Jennifer Lee, Agnieszka Denslow, Jacqueline Hewett, Jeffrey Bryant, Prajna Behara, Caitlin Goshert, Daniel Wambua, Ana De Almeida, Judith Jacques, Damian Deavall, James B. Rottman, Joseph C. Glorioso, Mitchell H. Finer, Brian B. Haines, Christophe Quéva, Lorena Lerner. Design of an Interferon-Resistant Oncolytic HSV-1 Incorporating Redundant Safety Modalities for Improved TolerabilityMolecular Therapy - Oncolytics 2020; 18 doi: 10.1016/j.omto.2020.08.004
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Daniel Stone, Martine Aubert, Keith R. Jerome. Adeno-associated virus vectors and neurotoxicity—lessons from preclinical and human studiesGene Therapy 2025; 32(1) doi: 10.1038/s41434-023-00405-1
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Yujing Zhang, Fang Xiao, Caigao Zhong, Ming Zeng, Lianhong Zou. Cd induces G2/M cell cycle arrest by up-regulating miR-133b via directly targeting PPP2R2D in L02 hepatocytesMetallomics 2018; 10(10) doi: 10.1039/c8mt00243f
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Alexandra C. Stanton, Kim A. Lagerborg, Liana Tellez, Allison Krunnfusz, Emily M. King, Simon Ye, Isaac H. Solomon, Mohammadsharif Tabebordbar, Pardis C. Sabeti. Systemic administration of novel engineered AAV capsids facilitates enhanced transgene expression in the macaque CNSMed 2023; 4(1) doi: 10.1016/j.medj.2022.11.002
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Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis. Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanomaThe FEBS Journal 2026;  doi: 10.1111/febs.70386
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Carina Henriques, Miguel M Lopes, Ana C Silva, Diana D Lobo, Romina Aron Badin, Philippe Hantraye, Luís Pereira de Almeida, Rui Jorge Nobre. Viral-based animal models in polyglutamine disordersBrain 2024; 147(4) doi: 10.1093/brain/awae012
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Yao Wang, Xianning Liu, Bei Wang, Hanhan Sun, Yiqian Ren, Hongbing Zhang. Compounding engineered mesenchymal stem cell-derived exosomes: A potential rescue strategy for retinal degenerationBiomedicine & Pharmacotherapy 2024; 173 doi: 10.1016/j.biopha.2024.116424
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Serkan Yilmaz, Yasemin Kartal. Comprehensive Hematology and Stem Cell Research2024;  doi: 10.1016/B978-0-443-15717-2.00100-1
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Levon M. Khachigian, Ramon L. Varcoe, Tuisku Suoranta, Nihay Laham-Karam, Seppo Ylä-Herttuala. Gene Therapeutic Strategies for Peripheral Artery Disease and New Opportunities Provided by Adeno-Associated Virus VectorsArteriosclerosis, Thrombosis, and Vascular Biology 2023; 43(6) doi: 10.1161/ATVBAHA.122.318902
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Pranjal Agarwal, Jugal Patil, Dhiraj Bhatia, Amit K. Yadav. microRNA Modulation: A Promising Combination Therapy for Cancer2026;  doi: 10.1007/978-981-95-5989-3_13
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Yismaw Alemie Alemayehu, Yared Abate Getahun. Harnessing the power of oncolytic viruses for advancing cancer therapyCancer Treatment and Research Communications 2026; 47 doi: 10.1016/j.ctarc.2026.101170
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Heng Li, Hironori Okada, Sadafumi Suzuki, Kazuhisa Sakai, Hitomi Izumi, Yukiko Matsushima, Noritaka Ichinohe, Yu-ichi Goto, Takashi Okada, Ken Inoue. Gene suppressing therapy for Pelizaeus-Merzbacher disease using artificial microRNAJCI Insight 2019; 4(10) doi: 10.1172/jci.insight.125052
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Ekaterina Gornostal, Almaqdad Alsalloum, Egor Degtyarev, Ekaterina Kuznetsova, Aygun Levashova, Daria Mishina, Natalia Mingaleva, Ali Mazloum, Viktor Bogdanov, Julia Krupinova, Sergey Mikhalkov, Irina Rybkina, Olga Mityaeva, Pavel Volchkov. An AAV-Based Therapy Approach for Neurological Phenotypes of X-Linked AdrenoleukodystrophyInternational Journal of Molecular Sciences 2025; 26(23) doi: 10.3390/ijms262311645
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Alisha Lalhall, Sagar Rana, Jogendra Singh Pawar, Smita Kumari. microRNA Modulation: A Promising Combination Therapy for Cancer2026;  doi: 10.1007/978-981-95-5989-3_3
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Anja Geisler, Ahmet Hazini, Lisanne Heimann, Jens Kurreck, Henry Fechner. Coxsackievirus B3—Its Potential as an Oncolytic VirusViruses 2021; 13(5) doi: 10.3390/v13050718
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Mohammad Shayestehpour, Sharareh Moghim, Vahid Salimi, Somayeh Jalilvand, Jila Yavarian, Bizhan Romani, Erkko Ylösmäki, Talat Mokhtari-Azad. Selective Replication of miR-145-regulated Oncolytic Adenovirus in MCF-7 Breast Cancer CellsFuture Virology 2016; 11(10) doi: 10.2217/fvl-2016-0069
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Matthew Benger, Maria Kinali, Nicholas D. Mazarakis. Autism spectrum disorder: prospects for treatment using gene therapyMolecular Autism 2018; 9(1) doi: 10.1186/s13229-018-0222-8
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Pedro Berraondo, Paolo G V Martini, Matias A Avila, Antonio Fontanellas. Messenger RNA therapy for rare genetic metabolic diseasesGut 2019; 68(7) doi: 10.1136/gutjnl-2019-318269
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Matías Gastón Pérez, Andrés Grecco, Mara Cecilia Rosenzvit. MicroRNA2022;  doi: 10.1016/B978-0-323-89774-7.00017-0
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Luca Grisorio, Rossana Bongianino, Matteo Gianeselli, Silvia Giuliana Priori. Gene therapy for cardiac diseases: methods, challenges, and future directionsCardiovascular Research 2024; 120(14) doi: 10.1093/cvr/cvae207
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Stefania Oliva, Manuela Gambella, Mario Boccadoro, Sara Bringhen. Systemic virotherapy for multiple myelomaExpert Opinion on Biological Therapy 2017;  doi: 10.1080/14712598.2017.1364359
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Martí Farrera-Sal, Cristina Fillat, Ramon Alemany. Effect of Transgene Location, Transcriptional Control Elements and Transgene Features in Armed Oncolytic AdenovirusesCancers 2020; 12(4) doi: 10.3390/cancers12041034