Minocycline fails to improve neurologic and histologic outcome after ventricular fibrillation cardiac arrest in rats

Table 1 Physiologic and biochemical profile after cardiac arrest

		BL	RT5	RT15	RT30	RT60	RT72H
HR (bpm)	Control	355 ± 21	335 ± 47	354 ± 20	378 ± 45	366 ± 26	N/A
	Minocycline	348 ± 20	335 ± 38	355 ± 21	369 ± 22	374 ± 28	N/A
MAP (mmHg)	Control	91 ± 5	98 ± 31	100 ± 20	89 ± 13	94 ± 19	N/A
	Minocycline	90 ± 9	98 ± 13	86 ± 11	94 ± 13	102 ± 9	N/A
pHa	Control	7.39 ± 0.02	7.12 ± 0.06c	7.24 ± 0.08c	7.37 ± 0.05	7.41 ± 0.03	7.38 ± 0.15
	Minocycline	7.46 ± 0.13	7.14 ± 0.04c	7.27 ± 0.05c	7.39 ± 0.03	7.42 ± 0.02	7.46 ± 0.15
paO2 (mmHg)	Control	136 ± 15	381 ± 56c	373 ± 41c	144 ± 36	136 ± 37	306 ± 187
	Minocycline	133 ± 14	378 ± 35c	384 ± 43c	145 ± 48	145 ± 38	427 ± 56c
paCO2 (mmHg)	Control	39 ± 3	51 ± 2c	45 ± 2c	40 ± 4	45 ± 5c	41 ± 17
	Minocycline	40 ± 4	51 ± 5c	47 ± 4c	40 ± 2	41 ± 2	35 ± 15
BE (mEq/L)	Control	-1.3 ± 1.5a	-12.6 ± 1.3c	-8.1 ± 4.2c	-1.8 ± 3.3	2.7 ± 1.9c	-1.8 ± 5
	Minocycline	0.5 ± 1.6	-12.1 ± 1.3c	-5.9 ± 2.1c	-0.2 ± 1.5	1.9 ± 1.6	0.0±3.5
Lactate (mmol/L)	Control	1.7 ± 0.6	13.0 ± 2.6c	9.7 ± 2.8c	5.4 ± 2.0c	2.0 ± 1.2	3.9 ± 1.1c
	Minocycline	1.2 ± 0.4	12.5 ± 1.6c	8.7 ± 1.4c	4.6 ± 1.0c	1.9 ± 0.7c	3.0 ± 0.7c
Hct (%)	Control	39 ± 1a	38 ± 2	39 ± 2	39 ± 2	37 ± 3a	43 ± 5c
	Minocycline	40 ± 1	38 ± 3	39 ± 2	40 ± 3	40 ± 1	41 ± 6
Glucose (g/dL)	Control	218 ± 28	325 ± 31c	277 ± 44c	213 ± 41	134 ± 24c	243 ± 48
	Minocycline	223 ± 16	337 ± 19c	293 ± 18c	205 ± 41	162 ± 51c	183 ± 15ac

BL: Baseline; RT: Resuscitation time; HR: Heart rate; MAP: Mean arterial pressure; BE: Base excess; Hct: Hematocrit; N/A: Not assessed.

^aP < 0.05 vs minocycline;

^cP < 0.05 vs respective baseline.