Critical care management and intensive care unit outcomes following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy

Table 1 Patient characteristics

Variable	n = 51
Age (yr)	56 (18-82)
Gender
Female	27 (53%)
APACHE II	15 (7-23)
ICU LOS (d)	4 (1-60)
Operative time (min)	413 (65-815)
Primary site
Colon	19
Appendix	12
Gastric	6
Ovarian	3
Pseudomyxoma peritoneii	6
Mesothelial	3
Others	2
EBL (mL)	1125 (50-6500)
Peritoneal cancer index (intraop)	13 (3-35)

Data are reported as median and range or n (%). ICU: Intensive care unit; LOS: Length of stay.

Table 2 Postoperative complications n (%)

Complication	n = 51
Acute respiratory failure	18 (33)
Postoperative hypovolemia	51 (100)
Postoperative hypotension	13 (25)
Septic shock	7 (13)
Reintubation	6 (12)
Acute blood loss anemia	18 (33)
Pulmonary embolism	4 (8)
Acute renal failure	5 (10)
Tracheostomy	4 (8)
Dilutional coagulopathy	28 (55)
Hypoalbuminemia	51 (100)
Arrythmias	2 (3)
CLABSI	0 (0)
ICU delirium	3 (6)
Surgical complications
Anastomotic leaks	8 (15)
Anastomotic leaks requiring OR	5
Intra abdominal abscess	5 (10)
Intra abdominal abscess requiring IR drainage	4
Surgical bleeding	4 (8)
Deep wound infection	4 (8)
Abdominal sepsis: Anastomotic leak, abscess, deep wound infection	17 (33)
Bacteremia	2 (3)
Postoperative parenteral nutrition	9 (18)

Data are reported as n (%). CLABSI: Central line associated bloodstream infection; ICU: Intensive care unit.

Table 3 Subgroup analysis of patients admitted to intensive care unit postoperatively vs admitted to the surgical floor

Variable, n (%)	ICU group	Non ICU group	P value
	n = 51	n =119
Age, mean (SD)	56.6 (12.8)	54.5 (10.5)	0.282
ASA, mean (SD)	3.1 (0.6)	2.8 (0.5)	0.009
ASA, > 3 (%)	12 (24)	8 (6.7)	< 0.001
Intraop PCI, mean (SD)	21.5 (8.4)	13.7 (8.3)	< 0.001
Change in PCI, mean (SD)	16.2 (7.1)	10.7 (6.1)	< 0.001
No. of resected organs: Mean (SD)	5.9 (2.2)	3.1 (2.1)	< 0.001
EBL, mean (SD)	1505 (1408)	423 (519)	< 0.001
Intraop transfusion (%)	45 (90)	26 (21.7)	< 0.001
OR time, min, mean (SD)	456 (122)	328 (118)	< 0.001
Mortality at
30 d (%)	2 (4)	2 (1.7)	0.36
90 d (%)	8 (12)	6 (5)	0.104
Hospital stay, mean (range)	18 (5-88)	8.6 (3-101)	< 0.001
Survival, mo: Median (SE)	14 (1.8)	33.4 (5.3)	< 0.001
Readmission rate to ICU (%)	6/51 (12)	3/119 (2.5)	0.01

ICU: Intensive care unit.