Ulinastatin for acute lung injury and acute respiratory distress syndrome: A systematic review and meta-analysis

Table 1 Quality and characteristics of all included studies

Ref.	Yr	Jadad score	Design	Sample size	Gender (male/female)	Age (yr, mean or range )	Dosage	Frequency	Duration (d)	Outcomes
Chen et al[10]	2006	1	NRCT	70	40/30	36.6	200000	bid	2-7	Oxygenation index
Gu et al[11]	2011	1	NRCT	120	65/55	56.2	100000	tid	5	Oxygenation index
Hu et al[12]	2009	1	NRCT	54	39/15	41.2	300000	tid	7	Oxygenation index Length of ICU stay 28-d mortality rate
Huang et al[13]	2010	1	NRCT	80	41/39	49	100000	tid	5	Oxygenation index Length of ICU stay ICU Mortality rate
Jiang et al[14]	2006	1	NRCT	57	32/25	58.1	200000	qd	7-10	Oxygenation index ICU Mortality rate
Liang et al[15]	2011	1	NRCT	62	36/26	38.8	200000	bid	7	Oxygenation index Length of ICU stay
Liang et al[16]	2008	1	NRCT	76	42/34	57	200000	bid	6	Oxygenation index ICU Mortality rate
Lu et al[17]	2008	1	NRCT	60	42/18	39.7	50000	qd	3	Oxygenation index
Ou et al[18]	2008	1	NRCT	36	24/12	63.7	200000-300000	bid	5-7	Oxygenation index ICU Mortality rate Incidence of MODS
Pi et al[19]	2009	1	NRCT	40	25/15	37	200000-	bid	5-7	Incidence of MODS ICU Mortality rate
Qian et al[20]	2009	1	NRCT	48	35/13	48	200000	qid	6	Oxygenation index ICU Mortality rate Length of ICU stay
Qin[21]	2007	1	NRCT	60	40/20	35	300000	bid	3	Oxygenation index
Shang et al[22]	2008	2	RCT	60	48/12	14-72	200000	tid	7	Oxygenation index ICU Mortality rate
Shi et al[23]	2011	1	NRCT	50	34/16	59.4	300000	bid	7-10	Oxygenation index ICU Mortality rate
Wang et al[24]	2011	1	NRCT	52	32/20	55.4	200000	tid	10	ICU Mortality rate
Wang et al[25]	2011	1	NRCT	60	44/16	18-60	200000	bid	5	Oxygenation index
Xiang et al[26]	2011	1	NRCT	72	46/26	46.8	200000	tid	7	Oxygenation index
Xiong[27]	2008	1	NRCT	50	28/22	35	300000	bid	7	Oxygenation index
Yang et al[28]	2011	1	NRCT	40	NA	NA	200000	tid	10	Oxygenation index
Yang et al[29]	2006	2	NRCT	80	58/22	14-72	300000	bid	7	Oxygenation index ICU Mortality rate
Zhang et al[30]	2009	1	NRCT	34	22/12	9-61	200000	tid	10	Oxygenation index ICU Mortality rate
Zhang et al[31]	2011	1	NRCT	82	43/39	18-65	200000	bid	7	Oxygenation index 28-d mortality rate
Zhang[32]	2010	2	RCT	60	45/15	43.3	300000	bid	7	Oxygenation index
Zhang et al[33]	2010	1	RCT	60	30/30	55.7	500000	bid	7	Oxygenation index Length of ICU stay 28-d mortality rate
Zhang et al[34]	2009	1	NRCT	61	54/7	61.9	200000	bid	7	Oxygenation index
Zhao et al[35]	2012	2	RCT	56	37/19	46.2	200000	bid	4	Oxygenation index
Zhao et al[36]	2007	1	NRCT	37	29/8	42.6	100000	bid	5	Oxygenation index ICU Mortality rate
Zheng et al[37]	2011	1	NRCT	60	42/18	40.2	50000	qd	3	Oxygenation index ICU mortality rate Length of ICU stay
Zhou et al[38]	2011	1	NRCT	40	NA	40.2	600000	qid	5	Oxygenation index ICU Mortality rate

NA: Not available; NRCT: Non-randomized controlled trial; RCT: Randomized controlled trial; ICU: Intensive care unit.