Elevated soluble fas blood concentrations in patients dying from spontaneous intracerebral hemorrhage

Table 1 Clinical and biochemical characteristics of 30 d surviving and non-surviving patients with spontaneous intracerebral hemorrhage

Variable	Surviving, n = 39	Non-surviving, n = 36	P value
Sex, n (%)			0.35
Female	13 (33.3)	16 (44.4)
Male	26 (66.6)	20 (55.6)
Age in yr, n (median P 25-75)	57 (51-63)	68 (57-75)	0.001
Cause of SIH, n (%)			0.99
Hypertension	35 (89.7)	33 (91.7)
Amyloid angiopathy	4 (10.3)	3 (8.3)
Volume of SIH in cc, n (median P 25-75)	41 (23-66)	72 (29-98)	0.04
Transtentorial herniation, n (%)	2 (5.1)	2 (5.6)	0.99
Hydrocephalus, n (%)	17 (43.6)	23 (63.9)	0.11
Intraventricular hemorrhage, n (%)	13 (33.3)	20 (56.6)	0.07
Site of SIH, n (%)			0.91
Lobar	24 (61.5)	23 (63.9)
Basal ganglia	7 (17.9)	7 (19.4)
Thalamus	8 (20.5)	6 (16.7)
Midline shift in mm, n (median P 25-75)	5 (0-8)	10 (5-15)	0.004
GCS, n (median P 25-75)	8 (6-8)	4 (3-7)	< 0.001
APACHE-II score, n (median P 25-75)	19 (15-21)	25 (23-28)	< 0.001
ICH score, n (median P 25-75)	2 (1-3)	3 (2-4)	< 0.001
aPTT in s, n (median P 25-75)	29 (26-30)	29 (24-33)	0.28
Platelets as × 103/mm3, n (median P 25-75)	208 (161-262)	200 (143-259)	0.83
Fibrinogen in mg/dL, n (median P 25-75)	402 (311-626)	487 (366-542)	0.42
INR, n (median P 25-75)	1.07 (0.94-1.21)	1.09 (0.90-1.21)	0.76
Lactic acid in mmol/L, n (median P 25-75)	1.60 (0.90-2.10)	1.75 (1.20-2.70)	0.07
Glycemia in g/dL, n (median P 25-75)	140 (120-194)	166 (133-211)	0.06
Sodium in mEq/L, n (median P 25-75)	140 (137-143)	139 (136-145)	0.79
Creatinine in mg/dL, n (median P 25-75)	0.80 (0.60-0.91)	0.80 (0.60-1.10)	0.90
PaO2/FIO2 ratio, n (median P 25-75)	296 (194-375)	270 (214-387)	0.83
Early hematoma evacuation, n (%)	15 (38.5)	6 (16.7)	0.04
sFas in ng/mL, n (median P 25-75)	22 (17-63)	141 (49-286)	< 0.001

APACHE II: Acute Physiology and Chronic Health Evaluation; aPTT: Activated partial thromboplastin time; FIO₂: Fraction inspired of oxygen; GCS: Glasgow Coma Scale; ICH: Intracerebral hemorrhage; INR: International normalized ratio; PaO₂: Pressure arterial of oxygen; SICH: Spontaneous intracerebral hemorrhage; SIH: Spontaneous intracranial hypotension.

Table 2 Multiple logistic regression analysis to predict 30 d mortality

Variable	Odds ratio	95%CI	P value
Serum sFas in ng/mL	1.070	1.014-1.129	0.01
ICH score as points	47.71	2.24-1012.34	0.01
Midline shift in mm	1.758	1.133-2.727	0.01
Early hematoma evacuation as yes vs no	0.002	0.001-0.210	0.01

CI: Confidence interval; ICH: Intracerebral hemorrhage.