Retrospective Study
Copyright ©The Author(s) 2022.
World J Crit Care Med. Jan 9, 2022; 11(1): 48-57
Published online Jan 9, 2022. doi: 10.5492/wjccm.v11.i1.48
Table 1 Baseline characteristics of study population

Remdesivir (n = 20)
Control (n = 25)
Mean age (yr)64.20 (± 15.16)68.32 (± 12.67)
Age groups in years (n, %)
18-40 2 (10)1 (4)
41-64 5 (25)7 (28)
Above 6513 (65)17 (68)
Females (n, %)11 (55)12 (48)
Race or ethnic group (n, %)
White or Caucasian9 (45)12 (48)
Hispanic5 (25)9 (36)
Black or African American2 (10)2 (8)
Other4 (20)2 (8)
Tobacco use (n, %)11 (55)14 (56)
Diabetes mellitus (n, %)13 (65)20 (80)
Hypertension (n, %)19 (95)24 (96)
Coronary artery disease/peripheral vascular disease (n, %)8 (40)9 (36)
Congestive heart failure (n, %)10 (50)12 (48)
History of lung disease- no. (%)6 (30)9 (36)
Obesity (BMI>30 kg/m2) (n, %)8 (40)12 (48)
Arrhythmia (n, %)6 (30)9 (36)
Length of stay - d (± SD) 13.00 (± 7.35)12.16 (± 8.38)
Treatment (n, %)
Corticosteroids20 (100)17 (68)
Antibiotics13 (65)13 (52)
Therapeutic anticoagulation9 (45)11 (44)
Table 2 Main effect parameter estimates for the primary outcomes and covariates

Outcome: Max O2
Outcome: Ventilation
Outcome: Time to Mortality
Variable
PE
X2 (1)
p
PE
X2 (1)
P value
PE
X2 (1)
P value
Age0.323.250.07120.040.560.45620.051.750.1860
Tobacco use8.593.820.05071.290.910.3399-0.890.910.3398
Female Sex-9.495.430.0198-2.943.800.05110.05< 0.010.9529
Black, Hispanic, and Other races7.022.690.10112.141.960.16141.181.910.1672
Obesity5.351.360.24441.460.740.39040.320.160.6932
Diabetes-20.595.210.0224-4.063.610.0575-4.179.250.0024
High d dimers-21.502.220.1358-0.01< 0.010.9971-5.867.410.0065
Remdesivir-25.936.650.0099-28.5222.98< 0.0001-5.037.420.0065
Table 3 Group mean comparisons
D dimers
Diabetes
Condition
Mean
Z
P value
Cohen's d
Outcome: Max O2
HighYesRemdesivir28.80-0.750.22600.43
Control36.81
NoRemdesivir46.232.380.00871.76
Control13.22
LowYesRemdesivir13.99-0.330.37120.09
Control15.72
NoRemdesivir8.79-2.060.01991.38
Control34.72
Outcome: Probability of being on a ventilator
D dimersDiabetesCondition% on ventilatorZpRisk ratio
HighYesRemdesivir6.16-1.210.11250.11
Control55.34
NoRemdesivir67.92-0.070.47080.90
Control75.47
LowYesRemdesivir8.220.270.39551.62
Control5.07
NoRemdesivir0.00-4.45< 0.00010.00
Control75.66
Outcome: Time to mortality
D dimersDiabetesConditionHazard ratioZpRisk ratio
HighYesRemdesivir-3.130.110.45705.78
Control-4.92
NoRemdesivir-5.98-0.020.49300.89
Control-5.86
LowYesRemdesivir-4.84-0.120.45120.52
Control-4.17
NoRemdesivir-5.03-2.720.00320.01
Control0.00