Should multi-gene panel testing replace limited BRCA1/2 testing? A review of genetic testing for hereditary breast and ovarian cancers

Table 1 List of select genes that can be found on multi-gene panels and associated cancer risks

Gene	Cancer risk1
ATM	Breast, pancreatic cancer
BARD1	Breast
BRCA1	Breast, ovarian, male breast cancer, melanoma, pancreatic cancer
BRCA2	Breast, ovarian, male breast cancer, melanoma, pancreatic, prostate cancer
BRIP1	Breast
CDH1	Breast, diffuse-type gastric cancer
CHEK2	Breast, colon, ovarian
EPCAM	Colorectal, uterine, stomach, ovarian
MLH1	Colorectal, uterine, stomach, ovarian
MRE11A	Breast
MSH2	Colorectal, uterine, ovarian
MSH6	Colorectal, uterine, stomach, ovarian
MUTYH	Breast, colorectal, other gastrointestinal sites
NBN	Breast
NF1	Breast, peripheral nerve sheath tumors, gliomas, leukemias, pheochromocytomas
PALB2	Breast, pancreatic cancer
PMS2	Colorectal, uterine, stomach, ovarian
PTEN	Breast, thyroid, endometrial cancer
RAD50	Breast
RAD51C	Breast, ovarian
RAD51D	Breast, ovarian
STK11	Breast, gastrointestinal, ovarian
TP53	Breast, ovarian, osteosarcomas, brain tumors, colorectal, other gastrointestinal sites

¹List of cancer sites is not all-inclusive as additional sites may be pending further clinical validation.