Subcutaneous and sublingual immunotherapy: Where do we stand?

Table 1 Head-to-head study characteristics with subcutaneous and sublingual

Ref.	Year	Allergen	Study design	No. of patients	Findings
Quirino et al[84]	1996	Grass pollen	Double-blind, double-dummy	SCIT (n = 10) SLIT (n = 10) No placebo group	Significant reduction in symptoms and medications for SCIT and SLIT groups ↑ Total specific IgG, ↑specific IgG4 and ↓skin reactivity for SCIT only
Mungan et al[83]	1999	Dust mite	Single-blind, placebo controlled	SCIT (n = 10) SLIT (n = 15) Placebo (n = 11)	↓ Rhinitis symptoms with SLIT ↓ Skin reactivity with SCIT ↑ Specific IgG4 with SCIT
Khinchi et al[82]	2004	Birch pollen	Randomized, double-blind, double-dummy, placebo-controlled	SCIT (n = 21) SLIT (n = 18) Placebo (n = 19)	Significant reduction in symptoms and medications for SCIT vs placebo and SLIT vs placebo No difference between SCIT and SLIT groups
Mauro et al[86]	2007	Birch pollen	Randomized, double-blind, double-dummy	SCIT (n = 19) SLIT (n = 15)	No difference in mean symptom and medication score between SCIT and SLIT Specific IgG4 with SCIT
Tahamiler et al[88]	2008	Dust mite	Open label, randomized	SCIT (n = 96) SLIT (n = 97)	↓ Rhinitis and conjunctivitis symptoms scores and nasal provocation score with SCIT and SLIT (greater improvement with SCIT)
Eifan et al[85]	2010	Dust mite	Open label, randomized, controlled	SCIT (n = 16) SLIT (n = 16) Pharmacotherapy (n = 16)	↓ Rhinitis and asthma symptom score, total medication score ↓ Skin reactivitiy with SCIT and SLIT ↓ Specific IgE with SCIT and SLIT
Keles et al[87]	2011	Dust mite	Open label, randomized, controlled	SCIT (n = 11) SLIT (n = 13) SCIT plus SLIT (n = 14) Pharmacotherapy (n = 12)	Reduction in total symptom score and total medication score in all immunotherapy groups ↓ Skin reactivity with SCIT ↑ Specific IgG4 for SCIT and SCIT plus SLIT
Yukselen et al[89]	2012	Dust mite	Randomized, double-blind, double-dummy, placebo-controlled	SCIT (n = 10) SLIT (n = 11) Placebo (n = 10 )	Significant reduction in rhinitis and astma symptom score with SCIT Skin reactivity with SCIT and SLIT ↑ Specific IgG4 with SCIT

SCIT: Subcutaneous immunotherapy; SLIT: Sublingual immunotherapy.