Spontaneous regression of renal cell carcinoma: Reality or myth?

Table 1 Regression of primary renal cell carcinoma

Case	Year	Type of regression	Histology documented	Follow up (interval)
Hall[53]	1908	Total regression (?)	Entirely necrotic tumor	Not given
Choi et al[33]	1986	Total regression (?)	Cyst-like capsule with necrotic tissue	Not given
			Calcifications and a cluster of tumor cells…
Edwards et al[34]	1996	Partial regression	Residual RCC with marked fibrosis	36 mo
			And calcification
Hamid et al[32]	1998	"Extensive regression"	Extensively hyalinised lesion, also foci	Not given
			Of cells with clear cytoplasm
			Cystic cavity containing necrotic	Not given
			Debris, occasional foci of viable RCC
Lacquaniti et al[35]	1999	Partial regression	Fibrotic involution…..	7 mo
			With few central areas of RCC
Kobayashi et al[8]	2002	Partial regression of primary	No	2 yr
		RCC with inferior V. cava
		Tumor thrombus

RCC: Renal cell carcinoma.

Table 2 Regression of metastases from renal cell carcinoma

Site of metastases	Source	Number of cases	Histological documentation	Follow up (interval)
Lung	Meinders[54]	1	No	3 yr
	Boasberg et al[25]	1	No	2.5 yr
	Cited by Freed et al[23]	45 (from 1928-1976)	13/45
	Vizel et al[55]	1	No	11 mo
	Mohr et al[56]	1	No	22 mo
	Snow et al[5]	1	Yes	6.5 yr
	Nakano et al[57]	1	No	8 yr
	Barré et al[58]	2	Yes	5 yr
	Kavoussi et al[36]	1	Yes (cytologically)	6 yr
	Eissler[59]	1	Yes	7 yr
	Omland et al[60]	1	No	14 mo
	Davis et al[37]	1	Cytologically	18 mo
	de Riese et al[14]	2	No	5.5-11 yr
	Vogelzang et al[61]	1	Yes (cytologically)	5 yr
	Palmer et al[62]	1	No	15 mo
	Garcia-Del-Muro et al[63]	1	No	1 yr
	Czaplicki et al[64]	1	Not given	16 yr
	Marcus et al[65]	4	No	1-4.5 yr
	MacManus et al[30]	1	Yes	9 mo
	Bos et al[24]	1	No	1 yr
	Edwards et al[34]	1	No	36 mo
	Lokich[7]	1	No	2 yr
	Rauh et al[66]	1	Yes	8 mo
	Chang et al[11]	1	Yes	16 mo
	Sánchez-Ortiz et al[67]	1	Yes	10 mo
	Lekanidi et al[29]	1	No	5 mo
Bone	Mims et al[68]	1	Yes	1 yr
	Doolittle[69]	1	Yes	4 yr
	Freed et al[23]	1	Yes	10 yr
	Kerbl et al[70]	1	Yes	13 mo
	Nakajima et al[71]	1	Yes	8 mo
Pleural/mediastinal	Kallmeyer et al[72]	1	Yes	3 mo
	Abubakr et al[27]	1	Yes	1.5 yr
	Thoroddsen et al[49]	1	Yes	9 yr
Liver	Deweerd et al[73]	1	Yes	6 mo
	Ritchie et al[74]	1	Yes	9 mo
	Wyczólkowski et al[75]	1	Yes	12 mo
	Christophersen et al[10]	1	Yes	5 yr
Pancreatic choroidal	Altschuler et al[76]	1	Yes	2.5 yr
	Langmann et al[38]	1	No	6 mo
	Hammad et al[40]	1	No
Brain	Omland et al[60]	1	No	14 mo
	Guthbjartsson et al[39]	1	No	9 yr
	Hensiek et al[77]	1	No	4 yr
Skin	Chang et al[11]	1	No	16 mo