Food protein-induced enterocolitis syndrome in children: An updated review on pathogenesis, diagnosis, and management

Table 1 Major and minor diagnostic criteria for food protein-induced enterocolitis syndrome

Category	Diagnostic criteria
Major criterion	Vomiting within 1–4 h after ingestion of the suspected food, in the absence of classic IgE-mediated allergic skin or respiratory symptoms
Minor criteria	≥ 2 episodes of repetitive vomiting after eating the same suspected food
	Repetitive vomiting episode 1–4 h after ingestion of a different food
	Extreme lethargy with any suspected reaction
	Marked pallor with any suspected reaction
	Need for emergency department evaluation following a suspected reaction
	Need for intravenous fluid support during a suspected reaction
	Diarrhea within 24 h (usually 5–10 h) after ingestion
	Hypotension or hypothermia