©Author(s) (or their employer(s)) 2026.
World J Clin Pediatr. Mar 9, 2026; 15(1): 112088
Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.112088
Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.112088
Table 1 Meta-regression summary comparing bilirubin/albumin ratio and total serum bilirubin in predicting bilirubin-induced neurologic dysfunction
| Predictor | Standardized mean difference | 95%CI | P value | Interpretation |
| B/A ratio (reference) | 1.71 | 1.00-2.41 | < 0.0001 | Strong, significant predictor of bilirubin-induced neurologic dysfunction |
| Total serum bilirubin (vs B/A) | -0.02 | -1.02 to 0.98 | 0.9628 | No significant difference from B/A ratio |
Table 2 Meta-regression summary with total serum bilirubin as the reference predictor for bilirubin-induced neurologic dysfunction
| Term | Value |
| Intercept | 1.6828 (P < 0.0001) |
| Variable bilirubin/albumin | +0.0238 (P = 0.9628) |
Table 3 Model statistics for meta-regression comparing bilirubin/albumin ratio and total serum bilirubin in predicting bilirubin-induced neurologic dysfunction
| Parameter | Value |
| Number of studies | 5 |
| Total comparisons | 10 |
| Heterogeneity (I2) | 91.7% |
| Tau2 (residual variance) | 0.5618 |
| R2 (variance explained by biomarker type) | 0% |
| Test for moderator (QM) | QM = 0.0022, P = 0.9628 (df = 1) |
- Citation: Ahmad N, Ahmed U, Mohy Ud Din G, Habib M, Luqman MS, Talha M, Saifullah M, Rana I. Comparison of bilirubin albumin ratio and total serum bilirubin for predicting neurological dysfunction in newborns: A meta-analysis. World J Clin Pediatr 2026; 15(1): 112088
- URL: https://www.wjgnet.com/2219-2808/full/v15/i1/112088.htm
- DOI: https://dx.doi.org/10.5409/wjcp.v15.i1.112088