Prevalence, phenotype and medication for the pediatric inflammatory bowel disease population of a state in Southeastern Brazil

Table 1 Demographic data from pediatric and adult patients diagnosed with inflammatory bowel disease in the state of Espírito Santo, from August 2012 to July 2014

Characteristics	Total amount		Age at diagnosis ≤ 17 yr		Age at diagnosis ≥ 18 yr		P value
	n	%	n	%	n	%
	1.048	(100)	55	(5.24)	993	(94.76)
Mean age at diagnosis (yr)	39.2	± 16.1	12,2	± 4.2	40,7	± 15.1	NA
Mean actual age (yr)	42.0	± 16.1	15,3	± 4.6	43,5	± 15.0	NA
Sex
Male	433	(41.3)	25	(44.6)	408	(41.1)	0.522
Female	615	(58.7)	30	(55.4)	585	(58.9)
IBD
Crohn's disease	357	(34.1)	30	(54.5)	327	(32.9)	0.004
Ulcerative colitis	669	(63.2)	24	(43.7)	645	(65)
Unclassified IBD	22	(2.1)	1	(1.8)	21	(2.1)

Continuous values are expressed as mean ± SD and analyzed. Proportions are expressed in n (%) and analyzed by the chi-square test. NA: Not available; IBD: Inflammatory bowel disease..

Table 2 Phenotype data of pediatric and adult inflammatory bowel disease patients, in the state of Espírito Santo, from August 2012 to July 2014

Characteristics	Total amount		Age at diagnosis ≤ 17 yr old		Age at diagnosis ≥ 18 yr old		P value
	n	%	n	%	n	%
	1.048	(100)	56	(5.34)	992	(94.66)
Ulcerative Colitis	669	(63.2)	24	(42.9)	645	(65.0)
Extension
E1	198	(30.3)	3	(12.5)	195	(31.0)	0.0371
E2	247	(37.9)	6	(25.0)	241	(38.4)	0.183
E3	209	(32.0)	15	(62.5)	194	(30.8)	0.001
Crohn's disease	352	(34.1)	30	(55.4)	322	(32.9)
Localization
L1	11	(31.4)	5	(16.1)	408	(41.1)	0.194
L2	102	(28.9)	10	(32.3)	584	(58.9)	0.861
L3	109	(30.4)	11	(35.5)	92	(28.6)	0.698
L4	11	(30.4)	1	(1.8)	10	(1)
L1+L4	8	(2.3)	1	(3.2)	7	(2.2)
L3+L4	12	(3.4)	2	(6.5)	10	(3.1)
Behavior
B1	200	(56.5)	18	(60.0)	182	(56.3)	0.686
B2	76	(21.5)	1	(3.3)	75	(23.3)	0.0051
B3	75	(21.2)	11	(36.7)	64	(19.5)	0.030
Perianal disease	92	(25.9)	14	(46.6)	78	(24.1)	0.007

¹Proportions are expressed in n (%) and analyzed using the Chi-square test and Fisher’s exact test. L1: Ileal; L2: Colonic; L3: Ileocolonic; L4: Upper gastrointestinal; B1: Inflammatory; B2: Stricturing; B3: Fistulizing; NA: Not available.

Table 3 Data on the use of biological therapy in patients with inflammatory bowel disease pediatric and adults, in the state of Espírito Santo, August 2012 to July 2014

Biological	Total amount		Age at diagnosis ≤ 17 yr old		Age at diagnosis > 18 yr old		P value
	n	%	n	%	n	%
	1.048	(100)	55	(5.24)	993	(94.76)
IBD	187	(17.8)	19	(34.5)	168	(16.9)	P = 0.001
CD	155	(43.5)	17	(56.7)	138	(42.2)	P = 0.126
UC	30	(4.5)	2	(8.3)	28	(4.3)	P = 0.353

IBD: Inflammatory bowel disease; UC: Ulcerative colitis; CD: Crohn's disease.