Observational Study
Copyright ©The Author(s) 2022.
World J Clin Pediatr. May 9, 2022; 11(3): 295-306
Published online May 9, 2022. doi: 10.5409/wjcp.v11.i3.295
Table 1 Clinical presentation of typical and atypical celiac disease
Clinical presentations
Typical, n = 120
Atypical, n = 79
P value
n%n%
Male6251.74151.90.974
Female 5848.33848.1
Chronic diarrhea 11999.211.3< 0.001
Abdominal distention 8369.23341.8< 0.001
Constipation 651316.50.007
Weight loss8167.549620.427
Anemia 11999.2791000.931
Short stature7461.75265.80.552
Hypocalcemia 8570.85265.80.455
Depression 0022.50.08
Skin lesion 2016.71113.90.764
Table 2 Type of anemia in typical and atypical celiac disease

Microcytic hypochromic
Normocytic normochromic
Macrocytic hypochromic
P value
n%n%n%0.931
Typical 11193.375.910.8
Atypical 7493.745.111.3
Table 3 Serological finding in both the typical and atypical groups

Typical, n = 120
Atypical, n = 79
P value
n%n%
Total IgA deficient 2218.3810.10.074
Anti-tTG IgA-positive5848.34860.80.086
Anti-tTG IgA-negative 4033.32329.10.315
Table 4 Histological findings in the typical and atypical celiac disease group
Marsh-Oberhuber classification
Typical, n = 120
Atypical, n = 79
P value
n%n%
06522.50.386
186.71012.70.149
20000
3a24202936.70.009
3b3125.82531.60.372
3c4739.21012.7< 0.001
3b-c43.333.80.862
Table 5 Histological findings in the seropositive (normal IgA level+ positive anti-tTG IgA) and seronegative (normal IgA level + negative anti-tTG IgA) celiac disease
Marsh-Oberhuber grade
CD seronegative, n = 63
CD seropositive, n = 106
P value
n%n%0.007
00076.6
1812.787.5
20000
3a2133.32018.9
3b2336.52927.4
3c1015.93634
3b-c11.665.7
Table 6 Histological findings in the seronegative typical and atypical celiac disease group
Marsh-Oberhuber classification
Typical, n = 40
Atypical, n = 23
P value
n%N%0.315
00000
1410417.4
20000
3a1332.5834.8
3b1332.51043.5
3c922.514.3
3b-c12.500
Table 7 Histological findings in the seropositive (106 patients) typical and atypical celiac disease group
Marsh-Oberhuber classification
Typical, n = 58
Atypical, n = 48
P value
n%n%0.022
058.624.2
135.2510.4
20000
3a610.31429.2
3b1424.11531.3
3c2746.6918.8
3b-c35.236.3