Salivary gland disorders: A comprehensive review

Table 1 World Health Organization 2005 Classification of salivary gland tumors

Epithelial tumors

Benign epithelial tumors

Pleomorphic adenoma

Myoepithelioma

Basal cell adenoma

Oncocytoma

Canalicular adenoma

Warthins tumors

Cystadenoma

Papillary cyst adenoma

Mucinous cyst adenoma

Benign sebaceous neoplasm

Sebaceous adenoma

Sebaceous lymphadenoma

Ductal papilloma

Intraductal

Inverted ductal

Sialadenoma papilliferum

Malignant epithelial tumors

Mucoepidermoid carcinoma

Acinic cell carcinoma

Adenoid cystic carcinoma

Polymorphous low grade adenocarcinoma

Epithelial myoepithelial carcinoma

Clear cell carcinoma

Basal cell adenocarcinoma

Oncocytic carcinoma

Myoepithelial carcinoma

Adenocarcinoma NOS

Carcinoma ex pleomorphic adenoma

Metastatising pleomorphic adenoma

Carcinosarcoma

Salivary duct carcinoma

Cyst adenocarcinoma

Low grade cribriform cystadenocarcinoma

Sialoblastoma

Malignant sebaceous tumor

Sebaceous adenocarcinoma

Sebaceous lymphadenocarcinoma

Squamous cell carcinoma

Mesenchymal tumors

Benign

Haemangioma

Haemangiopericytoma

Lipoma

Neurofibroma

Schwannoma

Malignant

Fibrosarcoma

Malignant fibrous histiocytoma

Liposarcoma

Malignant lymphoma

Metastatic tumor

Table 2 American College of Rheumatology Classification Criteria for Sjögren’s Syndrome: Sjogren’s syndrome case definition requires at least 2 out of the following 3

Positive serum anti-SSA and/or anti-SSB or (positive rheumatoid factor and ANA ≥ 1:320)

Ocular staining score ≥ 3

Presence of focal lymphocytic sialadenitis with focus score ≥ 1 focus/4 mm2 in labial salivary gland biopsies