Long-term survival of more than 3 years among patients with advanced non-small cell lung cancer treated with chemotherapy

Table 1 Patient’s characteristics (all patients) n (%)

Variables		No. of patients (n = 474)
Age (yr)
(median 64)	< 65	264 (55.7)
(range 23-85)	≥ 65	210 (44.3)
Gender
	Male	323 (68.1)
	Female	151 (31.9)
Performance status
(ECOG)	0	148 (31.2)
	1	240 (50.6)
	2	65 (13.7)
	3	20 (0.04)
	4	1 (0.002)
Smoking
	Yes	320 (67.5)
	No	154 (32.5)
Histology
	Adenocarcinoma	333 (70.3)
	Non-adenocarcinoma	141 (29.7)
Clinical stage
	IIIB	109 (23.0)
	IV	365 (77.0)

ECOG: Eastern Cooperative Oncology Group.

Table 2 Univariate and multivariate analysis in overall survival in all patients

Variables		Univariate analysis(log-rank test)P value	Multivariate analysis(Cox’s proportional hazard models)P value
Age (yr)	< 65/≥ 65	0.4158	0.5172
Gender	Male/Female	< 0.0001	0.0982
PS	0-1/2-4	< 0.0001	< 0.0001
Smoking	Yes/No	< 0.0001	0.1363
Histology	AC/Non-AC	< 0.0001	< 0.0001
Clinical stage	IIIB/IV	0.2151	0.5216

PS: Performance status; AC: Adenocarcinoma.

Table 3 Comparison of patient’s demographics between survivors (n = 65) of more than 3 yr and those (n = 409) of less than 3 yr

Variables		< 3 yr (n=409)	≥3 yr (n=65)	P value
Age	< 65/≥65	231/178	21/34	0.2267
Gender	Male/Female	290/119	33/32	0.0024
PS	0-1/2-4	329/80	60/5	0.0225
Smoking	Yes/No	291/118	35/30	0.0090
Histology	AC/Non-AC	268/141	65/0	< 0.0001
Clinical stage	IIIB/IV	91/318	18/47	0.3428

PS: Performance status; AC: Adenocarcinoma.

Table 4 Univariate analysis in overall survival in 65 long-term survivors

Variables		No. of patients	Univariate analysis (log-rank test) P value
Age	< 65/≥ 65	31/34	0.9448
Gender	Male/Female	33/32	0.3467
PS	0-1/2-3	60/5	0.7468
Smoking	Yes/No	35/30	0.9835
Clinical stage	IIIB/IV	18/47	0.7627

PS: Performance status.

Table 5 Univariate and multivariate analysis in overall survival in 60 long-term survivors

Variables		No. of patients	Univariate analysis (log-rank test) P value	Multivariate analysis (Cox’s proportionalhazard models) P value
Age	< 65/≥ 65	29/31	0.8099	0.9421
Gender	Male/Female	31/29	0.4133	0.3676
PS	0/1	35/25	0.0158	0.0244
Smoking	Yes/No	33/27	0.9062	0.5170
Clinical stage	IIIB/IV	18/42	0.8139	0.6781

PS: Performance status.