High-frequency electrical stimulation of cervical vagi reduces airway response to methacholine

Table 1 Baseline parameters in the Sal- and Ova-treated guinea pigs

Animals	RL	Cdyn	MABP	HR
	(cmH2O s/mL)	(mL/cmH2O)	(mmHg)	(bpm)
Sal (n = 9)	0.10 ± 0.02	0.35 ± 0.02	51.6 ± 1.6	327 ± 13
Ova (n = 8)	0.12 ± 0.02	0.34 ± 0.03	55.2 ± 3.7	311 ± 9

No significant differences of total lung resistance (R_L), dynamic pulmonary compliance (C_dyn), mean arterial blood pressure (MABP), or heart rate (HR) were found between the two groups.

Table 2 The reproducibility of total lung resistance responses to methacholine exposure controls

Group	Amplitude (%)			Duration (min)
	Trial 1	Trial 2	Trial 3	Trial 1	Trial 2	Trial 3
Sal	127 ± 25	136 ± 28	128 ± 30	7.9 ± 0.4	8.0 ± 0.5	7.5 ± 0.5
Ova	355 ± 58	370 ± 68	351 ± 63	8.2 ± 0.5	8.4 ± 0.5	7.7 ± 0.6

n = 9 for Sal- and Ova-treated guinea pigs for trial 1 and 2, and n = 5 for trial 3 for both groups; mean ± SE; no significant difference was found among the R_L amplitude and duration in response to the three methacholine exposures in both groups of animals. Sal: Saline; Ova: Ovalbumin.