Clinical implication of platelet to lymphocyte ratio in early onset preeclampsia: A single-center experience

Table 1 Primary characteristics of the studied group

Maternal demographic and biochemical parameter, n = 60
Maternal age in yr	27.0 ± 2.6
Mean systolic BP in mL/Hg	160.2 ± 5.2
Mean diastolic BP in mL/Hg	105.2 ± 4.7
Urine for albumin in gm/dL	2.89 ± 0.09
Serum creatinine in mg/dL	0.86 ± 0.52
Blood urea in mg/dL	29.38 ± 14.04
Alanine aminotransferase in U/L	27.43 ± 5.32
Aspartate aminotransferase in U/L	21.80 ± 4.49
Maternal hematological indices, n = 60
Hematocrit, 10%	36.58 ± 2.81
Platelet count as × 109	182.40 ± 47.42
MPV in fL	10.52 ± 0.23
PDW in fL	16.68 ± 1.37
PLR ratio	7.86 ± 1.75
Fetal demographic criteria, n = 60
Fetal AFI in cm	6.60 ± 1.19
Estimated fetal weight FW in kg	1.360 ± 0.08
PI UA Doppler	3.29 ± 0.59
RI UA Doppler	3.13 ± 0.55
Admission to NICU in d	7.09 ± 2.05
Mean Apgar score	6.54 ± 1.60

Data are mean ± SD. AFI: Amniotic fluid index; BP: Blood pressure; FW: Fetal weight; MPV: Mean platelet volume; NICU: Neonatal intensive care unit; PDW: Platelet distribution width; PI: Pulsatility index; PLR: Platelet to lymphocyte ratio; RI: Resistance index; UA: Uterine artery.

Table 2 Maternal outcome for the enrolled participants, n = 60

Parameter	Study participants presented	n (%)	P value
Mode of delivery	Vaginal delivery	21 (35)	< 0.407
	Cesarean delivery	39 (65)
Indication for CS delivery	Previous scar	13 (22.5)	< 0.190
	Fetal distress	12 (20)
	Failed induction	11 (17.5)
	Malpresentation	3 (5)

Table 3 Neonatal outcome of the delivered newborn (n = 60) presented as numbers and percentage

Variable		Admitted, n = 37	Not admitted, n = 23	P value
Meconium	Meconium stain	26 (70%)	0 (0%)	0.000
	No meconium	11 (30%)	23 (100%)
Occurrence of FGR	FGR	21 (56.7%)	0 (0%)	0.000
	No FGR	16 (43.3%)	23 (100%)
Apgar score	> 7	0 (0%)	19 (51.3%)	0.000
	5-7	5 (21.7%)	18 (48.7%)
	< 5	23 (78.3%)	0 (0%)
Occurrence of dead fetus	Dead fetus	2 (5%)	0 (0%)	0.257
	Not dead fetus	35 (95%)	23 (100%)

FGR: Fetal growth restriction.

Table 4 Correlation between the platelet to lymphocyte ratio and the studied variables

PLR vs variables	Correlation coefficient	P value
AFI	0.98	< 0.001
EFW	0.97	< 0.001
PI	-0.99	< 0.001
RI	-0.98	< 0.001
Apgar score	0.69	< 0.0001
Admission days to NICU	-0.98	< 0.0001

AFI: Amniotic fluid index; EFW: Estimated fetal weight; NICU: Neonatal intensive care unit; PI: Pressure index; PLR: Platelet to lymphocyte ratio; RI: Resistance index; UA: Uterine artery.

Table 5 Receiver operating characteristic curve defined the platelet to lymphocyte ratio cutoff value that discriminated fetal growth restriction with the utmost sensitivity and specificity

Parameter	Cutoff value	Sensitivity	Specificity	AUC	P value
PLR	< 7.49	100%	80%	0.9	< 0.001

AUC: Area under the curve; PLR: Platelet to lymphocyte ratio.