Impact of pelvic radiotherapy on the female genital tract and fertility preservation measures

Figure 1 The effect of pelvic radiotherapy on oocyte population according to the Faddy-Gosden model. Faddy-Gosden model (Source[20], with permission) as extended by Wallace et al[21]. The graph illustrates the effect of total body irradiation with 14 Gy at 10 years, predicting ovarian failure at 13 years.

Figure 2 Typical radiotherapy dose distribution for cervical cancer. A: Coronal view; B: Sagittal view. The red area receives > 40 Gy, green > 10 Gy and blue < 10 Gy. Ovarian positions are contoured in yellow within the treated area, and transposition to the lateral para-colic region is required to be outside the low dose radiation region.