Fecal microbiota transplant and dermatologic disorders: A retrospective cohort study assessing the gut microbiome’s role in skin disease

Table 1 Demographics of fecal microbiota transplant patients

	Total (n = 109)	Post-FMT skin condition noted (n = 19)	No post-FMT skin condition noted (n = 90)	P values
Sex, n (%)				0.72
Male	42 (38.5)	8 (42.1)	34 (37.8)
Female	67 (61.5)	11 (57.9)	56 (62.2)
Ethnicity, n (%)				0.72
Hispanic or Latino	5 (4.6)	0 (0.0)	5 (5.6)
Not Hispanic or Latino	102 (93.6)	19 (100.0)	83 (92.2)
Undisclosed or unknown	2 (1.8)	0 (0.0)	2 (2.2)
Age				0.96
Mean (± SD)	43.6 (±18.9)	43.4 (±18.5)	43.7 (±19.1)
Median (range)	38 (17-90)	39 (21-90)	38 (17-87)
History of Crohn's disease, n (%)a,b				0.022d
Yes	19 (17.4)	7 (36.8)	12 (13.3)
No	90 (82.6)	12 (63.2)	78 (86.7)
History of ulcerative colitis, n (%)a				0.76
Yes	21 (19.3)	4 (21.1)	17 (18.9)
No	88 (80.7)	15 (78.9)	73 (81.1)
History of solid organ transplant, n (%)a				0.21
Yes	5 (4.6)	2 (10.5)	3 (3.3)
No	104 (95.4)	17 (89.5)	87 (96.7)
Antibiotic use within eight weeks post-FMT, n (%)				0.77
Yes	25 (22.9)	5 (26.3)	20 (22.2)
No	84 (77.1)	14 (73.7)	70 (77.8)
Skin conditions pre-FMT, n (%)				0.63
Yes	8 (7.3)	2 (10.5)	6 (6.7)
No	101 (92.7)	17 (89.5)	84 (93.3)
Number of FMT procedures per patient, n (%)c				0.047d
One	82 (75.2)	15 (78.9)	67 (74.4)
Two	24 (22.0)	2 (10.5)	22 (24.4)
Three	3 (2.8)	2 (10.5)	1 (1.1)

^aPatients were classified based on cumulative history from all fecal microbiota transplant events for that patient, if more than one fecal microbiota transplant event.

^bOf note, one Crohn's disease patient could also be considered to have undifferentiated inflammatory bowel disease given the nature of their condition.

^cThis includes only fecal microbiota transplant procedures completed at University of Utah Health. Procedures completed elsewhere were excluded.

^dP < 0.05. FMT: Fecal microbiota transplant.

Table 2 Months between fecal microbiota transplant events and dermatology visits

Visit	Number of events	mean ± SD months to visit	Median months to visit	Minimum months to visit	Maximum months to visit
1st	26	10.0 ± 7.0	9.5	0	22
2nd	10	11.5 ± 6.4	11	5	23
3rd	7	12.0 ± 5.0	13	6	20
4th	4	12.5 ± 4.4	14.5	6	15
5th	3	16.3 ± 1.5	16	15	18
6th	1	16.0 ± ---	16	16	16
7th	1	17.0 ± ---	17	17	17
8th	1	18.0 ± ---	18	18	18