Mycosis fungoides: A mimicker of benign dermatoses

Table 1 Review of hitherto published cases of clinical masqueraders of mycosis fungoides

Leading clinical sign	Differential diagnosis	Ref.
Eczematous	Seborrhoeic eczema	Nashan et al[1], Van Doorn et al[31]
	Rosacea	Sherertz et al[32]
	Atopic eczema	Kazakov et al[33]
	Palmoplantar eczema	Spieth et al[34], Goldberg et al[35]
	Perioral dermatitis	Spieth et al[34]
	Other	Spieth et al[34]
Psoriasiform	Psoriasis palmoplantaris	Spieth et al[34], Nashan et al[1]
	Psoriasis vulgaris	Zackheim et al[36]
	Tinea corporis	Chave et al[37]
	Chronic discoid lupus erythematodes	Veysey et al[38]
	Tinea pedum	Hubert et al[39]
	Erysipelas	Brill et al[40]
Erythematous	Annular erythema	Lim et al[41], Cogrel et al[42], Bernardini et al[43]
	Erythema multiforme	Kazakov et al[33]
Alopecia	Alopecia areata	Burg et al[44]
Hypopigmented	Pityriasis versicolor	Kazakov et al[33]
	Pityriasis alba	Whitmore et al[45]
	Vitiligo	Ardigó et al[46]
	Leprosy	Kazakov et al[33]
	Postinflammatory hypopigmentation	Kazakov et al[33]
Hyperpigmentated	Acanthosis nigricans	Willemze et al[47], Barnhill et al[48]
	Ashy dermatosis	Kazakov et al[33]
	Lichen aureus	Fink-Puches et al[19]
	Purpura pigmentosa	Barnhill et al[48]
Bullous	Bullous pemphigoid	Kneitz et al[49]
	Pemphigus vulgaris	Roenigk et al[50]
	Mucositis	Wain et al[51]
Hyperkeratotic	Verruca vulgaris	Goldberg et al[35], Wobser et al[52]
	Keratosis lichenoides chronica	Bahadoran et al[53]
	Ichthyosis	Eisman et al[54], Kütting et al[55], Badawy et al[56]
	Follicular hyperkeratosis	Klemke et al[57]
	Porokeratosis Mibelli	Breneman et al[58]
	Seborrhoeic keratosis	Bazza et al[59]
	Bowen´s disease	Yoo et al[60]
	Pseudolymphoma	Marzano et al[61]
Papular	Papuloerythroderma Ofuji	Hur et al[12], Pereiro et al[62], Nashan et al[1]
	Comedones, cysts	Peris et al[63], Lacour et al[64], Oliwiecki et al[65], Vollmer et al[66]
Pustular	Palmoplantar pustulosis	Moreno et al[67]
	Generalized pustulosis	Camisa et al[68]
	Pyoderma gangraenosum	Ho et al[69], Carbia et al[70]
Granulomatous	Granuloma annulare	Jouary et al[25], Goerdt et al[71], Topar et al[72], Kempf et al[7], van Haselen et al[73]
	Rosacea	Spieth et al[34]
	Sarcoidosis	Bessis et al[74]
	Necrobiosis	Woollons et al[75]
Others	Gangrene	Goldstein et al[76]
	other tumors	Machler et al[77], Morcos et al[78]
	cutis laxa	Bessis et al[74]
All	12 major clinical signs
	47 differential diagnoses

Table 2 Clinical, histological and molecular genetic features of our own encountered cases of dermatological mimickers of mycosis fungoides

				Otherwise classical MF lesions
Patient	Leadingclinical sign	Differential diagnosis	Otherwiseatypical lesions	At timeof presentation	Duringclinical course	Histologicalfindings	Moleculargenetic findings
1	Erythematous	Erythema exsudativum multiforme	Yes	Yes	Yes	Classical MF	Not done
	Psoriasiform	Tinea corporis				Classical MF
	Granulomatous	Granuloma anulare				Classical MF
2	Papular	Papuloerythroderma Ofuji	No	No	No	MF/SS with folliculotropism, only slight epidermotropism	Monoclonal
3	Psoriasiform	Psoriasis	No	Yes	Yes	Classical MF	Monoclonal
4	Granulomatous	Granuloma anulare	No	Yes	Yes	Transformed MF with folliculotropism and giant cells	Biclonal
5	Hyperpigmented	Urticaria pigmentosa	No	No	Yes	Purpuric CD8+ MF	Monoclonal
6	Hypopigmented	Vitiligo	No	Yes	Yes	Purpuric CD8+ MF	Monoclonal
7	Hyperkeratotic	Plantar eczema	No	No	No	Classical MF	Monoclonal
8	Ulcerative	venous ulcer	No	Yes	Yes	Tumor stage MF	Not done
9	Eczematous	Rosacea	Yes	No	No	Folliculotropic MF	Polyclonal
	Granulomatous	Anetoderma				MF with elastolysis
10	Bullous	Bullous pemphigoid	No	Yes	Yes	CD8+ and CD30+ MF, subepidermal blistering	Monoclonal

MF: Mycosis fungoides; SS: Sézary syndrome.