Looking within the lesion: Large scale transcriptional profiling of psoriatic plaques

Table 1 Psoriasis susceptibility loci identified using genome-wide association studies

Psoriasis	Chromosome	Gene	Locus	Ref.
1	1p31.3	IL-23R		Nair et al[11]
1	1p31.3	IL-23R		Liu et al[48]
1	1p31.3	IL-23R	rs9988642	Tsoi et al[8]
2	1p36	RUNX3	rs7536201	Tsoi et al[8]
3	1p36.11	IL28RA	rs7552167	Tsoi et al[8]
4	1p36.23	SLC45A1, TNFRSF9	rs11121129	Tsoi et al[8]
5	1q21	PSORS4		Julià et al[49]
6	1q21	LCE3D	rs6701216	Liu et al[48]
7	1q21.3	LCE3B	rs4112788	de Cid et al[1]
8	20q12-q13.12	NCOA5	rs2903908	Zervou et al[50]
9	20q12-q13.2	CD40	rs4810485	Zervou et al[50]
10	20q13.13	RNF114	rs1056198	Tsoi et al[8]
11	22q11.21	UBE2L3	rs4821124	Tsoi et al[8]
12	2p15	B3GNT2	rs10865331	Tsoi et al[8]
13	2p16.1	FLJ16341, REL	rs62149416	Tsoi et al[8]
14	2q14.2	IL1RN		Julià et al[49]
15	2q24.2	KCNH7, IFIH1	rs17716942	Tsoi et al[8]
16	3p12.1	CADM2		Hiruma et al[51]
17	4q27			Liu et al[48]
18	5q15	ERAP1	rs27432	Tsoi et al[8]
19	5q31	IL-13, IL-4	rs1295685	Tsoi et al[8]
20	5q31.1-q33.1	IL-12B	rs12188300	Tsoi et al[8]
21	5q32-q33.1	TNIP1	rs17728338	Bowes et al[52]
22	6p21.3	HLA-C		Knight et al[53]
23	6p25.3	EXOC2, IRF4	rs9504361	Tsoi et al[8]
24	6q21	TRAF3IP2	rs33980500	Ellinghaus et al[10]
25	6q23	TNFAIP3	rs582757	Tsoi et al[8]
26	6q25.3	TAGAP	rs2451258	Tsoi et al[8]
27	7p14.1	ELMO1	rs2700987	Tsoi et al[8]
28	9p12	DDX58	rs11795343	Tsoi et al[8]
29	9q31	KLF4	rs10979182	Tsoi et al[8]
30	9q34	TSC1	rs1076160	Bowes et al[52]
31	10q22.3	ZMIZ1	rs1250546	Tsoi et al[8]
32	11q11-q13	RPS6KA4, PRDX5	rs645078	Tsoi et al[8]
33	11q22.3	ZC3H12C	rs4561177	Tsoi et al[8]
34	11q23.3	ETS1	rs3802826	Tsoi et al[8]
35	12q13.3	STAT2, IL23A	rs2066819	Tsoi et al[8]
36	13q12	LHFP		Liu et al[48]
37	13q14.11	COG6	rs7993214	Liu et al[48]
38	14q13	NFKBIA	rs8016947	Tsoi et al[8]
39	15q21		rs3803369	Liu et al[48]
40	16p11.2	PRSS53, FBXL19	rs12445568	Tsoi et al[8]
41	16p13.13	PRM3, SOCS1	rs367569	Tsoi et al[8]
42	17q11.2-q12	NOS2	rs28998802	Tsoi et al[8]
43	17q21.31	PTRF, STAT3, STAT5A/B	rs963986	Tsoi et al[8]
44	17q25	CARD14	rs11652075	Tsoi et al[8]
45	18q21.2	POL1, STARD6, MBD2	rs545979	Tsoi et al[8]
46	18q22.1	SERPINB8		Julià et al[49]
47	19p13.2	TYK2	rs34536443	Tsoi et al[8]
48	19p13.2	ILF3, CARM1	rs892085	Tsoi et al[8]

Note that many of the loci were identified in multiple studies (e.g., shaded).

Table 2 Transcriptional profiling studies targeting psoriasis in the GEO database

	Microarrays	Platform	Samples	Ref.
Comparison studies
GSE34248	14 + 14	HG-U133_Plus_2	Lesional + NonLes	[21]
GSE41662	24 + 24	HG-U133_Plus_2	Lesional + NonLes	[21]
GSE41663	15 + 15 (+ 51 treated)	HG-U133_Plus_2	Lesional + NonLes	[21]
GSE30999	85 + 85	HG-U133_Plus_2	Lesional + NonLes	[19]
GSE11903	15 + 15 (+ 59 treated)	HG-U133A_2	Lesional + NonLes	[18]
GSE6710	13 + 13	HG-U133A	Lesional + NonLes	[24]
GSE14905	21 + 33 + 30	HG-U133_Plus_2	Healthy + Les + NonLes	[16]
GSE13355	64 + 58 + 58	HG-U133_Plus_2	Healthy + Les + NonLes	[12]
GSE32407	20 + 20 (+ 20 IFNg treated)	HG-U133A_2	Healthy + NonLes	[17]
Related studies
GSE42305			Monocytes	[54]
GSE41905			Kcytes transfected wt Antimir31	[55]
GSE31652			All lesional, treated placebo	[56]
GSE26952			Nonlesional only Psor AD	[57]
GSE18948			PBMCs	[58]
GSE11307			PCR study	1
GSE6601			Psor vs AD	[59]
GSE41745	3 + 3		RNA Sequencing	[60]
GSE26866	11 + 11 (different regions)	HG-U133A_2	Single vs double amplification	[61]
GSE30768	2 +4 (+ 8 flare and relapse)	HG-U133A_2	Small number of samples	[62]
GSE2737	3 + 4 + 4	HG_U95Av2	Small array	[63]

¹Shin J and Detmar M, unpublished. PBMCs: Peripheral blood mononuclear cell; PCR: Partido comunista revolucionario.