Association of adiponectin gene polymorphisms with knee osteoarthritis

Table 1 Genotype distributions and allele frequencies of adiponectin gene +45T/G (rs2241766) single-nucleotide polymorphism in control and osteoarthritis groups

+45T/G SNP (rs2241766)		Control n (%)	OA n (%)	OR (95%CI)	P
Genotype	TT	96 (48.98)	84 (41.6)	1	-
	TG	75 (38.27)	93 (46)	1.417 (0.929-2.162)	0.106
	GG	25 (12.75)	25 (12.4)	1.143 (0.611-2.139)	0.676
Allele	T	267 (68.11)	261 (64.6)	1
	G	125 (31.89)	143 (35.4)	1.170 (0.872-1.571)	0.295

OA: Osteoarthritis; SNP: Single-nucleotide polymorphism.

Table 2 Genotype distributions and allele frequencies of the adiponectin gene +276G/T (rs1501299) single-nucleotide polymorphism in control and osteoarthritis groups

+276G/T SNP (rs1501299)		Control n (%)	OA n (%)	OR (95%CI)	P
Genotype	GG	102 (52)	106 (52.5)	1	-
	GT	77 (39.3)	76 (37.6)	0.950 (0.626-1.442)	0.809
	TT	17 (8.7)	20 (9.9)	1.132 (0.561-2.283)	0.729
Allele	G	281 (71.68)	288 (71.29)	1
	T	111 (28.32)	116 (28.71)	1.020 (0.750-1.387)	0.901

OA: Osteoarthritis; SNP: Single-nucleotide polymorphism.

Table 3 Based on radiographic severity of osteoarthritis, genotype distribution of adiponectin gene +45T/G polymorphism in osteoarthritis patients

OA severity	Genotype			P	aP
KL system	TT	TG	GG
Grade 2	27	30	8
Grade 3	29	29	8	NS
Grade 4	28	34	9	NS	NS

P value for difference in distribution of genotype between grade 2 and grade 3 or grade 4.

^aP value for genotype distribution between grade 3 and grade 4. OA: Osteoarthritis; KL: Kellgren-Lawrence; NS: Not significant.

Table 4 Based on radiographic severity of osteoarthritis, genotype distribution of adiponectin gene +276G/T polymorphism in osteoarthritis patients

OA severity	Genotype			P	aP
KL system	GG	GT	TT
Grade 2	20	29	5
Grade 3	41	22	8	0.037
Grade 4	45	25	7	0.046	NS

P value for difference in distribution of genotype between grade 2 and grade 3 or grade 4.

^aP value for genotype distribution between grade 3 and grade 4. OA: Osteoarthritis; KL: Kellgren-Lawrence; NS: Not significant.