MiR 26a as a stage-dependent biomarker and therapeutic regulator of inflammation in knee osteoarthritis

doi:10.5312/wjo.120195

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Orthop. Jul 18, 2026; 17(7): 120195
Published online Jul 18, 2026. doi: 10.5312/wjo.120195

Table 1 Primer sequences used

Name	Sequence 5’→ 3’	Sequence 3’→ 5’
miRNA-26a2-3p SL	ACAAAGCAGCATAGGTCACGCTTATGGAGCCTGGGACGTGACCTATGCTG	GTCGTATCCAGTGCAGGGTCCGAGGTATTCGCACTGGATACGACGAAACA
miRNA-26a-2-3p F	CTTTGTTCATTAGTTCTTATCC	CCTATTCTTGATTACTTGTTTC
miRNA-26a-5p SL	GTCGTATCCAGTGCAGGGTCCGAGGTATTCGCACTGGATACGACAGCCTA	ATCCGACAGCATAGGTCACGCTTATGGAGCCTGGGACGTGACCTATGCTG
miRNA-26a-5p F	TTCAAGTAATCCAGGATAGGCT	TCGGATAGGACCTAATGAACTT
U6 SL	GTCGTATCCAGTGCAGGGTCCGAGGTATTCGCACTGGATACGACAAAAATATG	GTATAAAAACAGCATAGGTCACGCTTATGGAGCCTGGGACGTGACCTATGCTG
U6 F	GCGCGTCGTGAAGCGTTC	CTTGCGAAGTGCTGCGCG
URP	GTGCAGGGTCCGAGGT	TGGAGCCTGGGACGTG
NF-κB F	GAGACATCCTTCCGCAAACT	TCAAACGCCTTCCTACAGAG
NF-κB R	GGTCCTTCCTGCCCATAATC	CTAATACCCGTCCTTCCTGG
COX2 F	ATTGACAGTCCACCAACTTACA	ACATTCAACCACCTGACAGTTA
COX2 R	CAGGAGGAAGGGCTCTAGTAT	TATGATCTCGGGAAGGAGGAC
MMP13 F	GTTTGGTCCGATGTAACTCCTC	CTCCTCAATGTAGCCTGGTTTG
MMP13 R	GAAGTCGCCATGCTCCTTAAT	TAATTCCTCGTACCGCTGAAG
NOS2 F	CTCAGCCTCATTCCTGCTTTA	ATTTCGTCCTTACTCCGACTC
NOS2 R	GACCTGTGCCTTGAGAACTT	TTCAAGAGTTCCGTGTCCAG
Beta Actin F	GGATCAGCAAGCAGGAGTATG	GTATGAGGACGAACGACTAGG
Beta Actin R	AGAAAGGGTGTAACGCAACTAA	AATCAACGCAATGTGGGAAAGA

Full Size Table

Table 2 Demographic characteristics of study population

Category	Control group (n = 50)	KOA patients (n = 50)
Mean age (years)	39.67 ± 7.4	65.3 ± 10.2
Gender distribution	22 males (44%)	12 males (24%)
Gender distribution	28 females (56%)	38 females (76%)
KOA grade (Kellgren-Lawrence)	-	Grade 1 16
		Grade 2 22
		Grade 3 12
Comorbidities	–	Hypertension + diabetes: 8
		Hypertension only: 11
		Diabetes only: 5

KOA: Osteoarthritis of the knee.

Full Size Table

Citation: Gunamala V, Hari R, Jeyaraman N, Nallakumarasamy A, Muthu S, Jeyaraman M. MiR 26a as a stage-dependent biomarker and therapeutic regulator of inflammation in knee osteoarthritis. World J Orthop 2026; 17(7): 120195
URL: https://www.wjgnet.com/2218-5836/full/v17/i7/120195.htm
DOI: https://dx.doi.org/10.5312/wjo.120195

Gunamala V, Hari R, Jeyaraman N, Nallakumarasamy A, Muthu S, Jeyaraman M. MiR 26a as a stage-dependent biomarker and therapeutic regulator of inflammation in knee osteoarthritis. World J Orthop 2026; 17(7): 120195 [DOI: 10.5312/wjo.120195]

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