Osthole exerts osteoprotective effect by activating ER, PI3K/AKT, MEK/ERK, and Wnt/β-catenin signaling pathways

doi:10.5312/wjo.121526

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World Journal of Orthopedics

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2218-5836

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Orthop. Oct 18, 2026; 17(10): 121526
Published online Oct 18, 2026. doi: 10.5312/wjo.121526

Table 1 Primer sequences used for quantitative real-time polymerase chain reaction

Gene	Primer sequences
OPG	Forward 5’-GCTAACCTCACCTTCGAG-3’
OPG	Reverse 5’-TGATTGGACCTGGTTACC-3’
RANKL	Forward 5’-AACAGGCCTTTCAAGGAGCTGTGC-3’
RANKL	Reverse 5’-AAGAGGACAGACTCACTTTATGGG-3’
Osterix	Forward 5’-ATGCAGGCATTTCACCAGGCCC-3’
Osterix	Reverse 5’-TGCTCAGGTGGTCACTTCGGGT-3’
TRAP	Forward 5’-TAACCGTCACCTGGCTGAAC-3’
TRAP	Reverse 5’-CACGGGACCCTAGTGCATTT-3’
CTR	Forward 5’-TCACTGCTACATGTCACGCC-3’
CTR	Reverse 5’-GTCACTGTCAAGGGTCCAGT-3’
RANK	Forward 5’-GCATCCCTTGCAGCTCAACA-3’
RANK	Reverse 5’-ATGGAAGAGCTGCAGACCAC-3’
CatK	Forward 5’-CCGAAAAGAGCCTAGCGAAC-3’
CatK	Reverse 5’-GGTCATGTCTCCCAAGTGGT-3’
MMP-9	Forward 5’-CCAGCCGACTTTTGTGGTCT-3’
MMP-9	Reverse 5’-TGGCCTTTAGTGTCTGGCTG-3’
β-actin	Forward 5’-TGGAATCCTGTGGCATCCATGAAAC-3’
β-actin	Reverse 5’-TAAAACGCAGCTCAGTAACAGTCC-3’

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Citation: Zhu TY, Yuan M, Wen XC, Tian CC, Han YH, Zheng C, Wu YT, Xia Q, Wang Y. Osthole exerts osteoprotective effect by activating ER, PI3K/AKT, MEK/ERK, and Wnt/β-catenin signaling pathways. World J Orthop 2026; 17(10): 121526
URL: https://www.wjgnet.com/2218-5836/full/v17/i10/121526.htm
DOI: https://dx.doi.org/10.5312/wjo.121526

Zhu TY, Yuan M, Wen XC, Tian CC, Han YH, Zheng C, Wu YT, Xia Q, Wang Y. Osthole exerts osteoprotective effect by activating ER, PI3K/AKT, MEK/ERK, and Wnt/β-catenin signaling pathways. World J Orthop 2026; 17(10): 121526 [DOI: 10.5312/wjo.121526]

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