Meta-Analysis
Copyright ©The Author(s) 2023.
World J Orthop. Jan 18, 2023; 14(1): 23-41
Published online Jan 18, 2023. doi: 10.5312/wjo.v14.i1.23
Table 1 Characteristics of included studies
Sl. No
Ref.
Country
Nature of study
Kellgren Lawrence Grade
Sample size
Treatment/control
Mean age (SD)
Male/female
MSC type
MSC source
Follow-up (mo)
Treatment group
Control group
Treatment group
Control group
1Vega et al[23], 2015SpainRCTII, III, IV3015/1556.6 ± 9.2457.3 ± 9.0906/0905/10BMAllo12
2Vangsness et al[24], 2014United StatesRCTNR5536/1944.6 ± 9.8247.8 ± 825/1113/06BMAllo24
3Garay-Mendoza et al[25], 2018MexicoRCTNR6130/3155.57 ± 12.0259.32 ± 10.8507/2309/22BMAuto6
4Kuah et al[26], 2018AustraliaRCTI, II, III2016/450.8 ± 7.2955.0 ± 10.4211/0501/03AD Allo12
5Estrada et al[22], 2020ArgentinaRCTI, II, III8960/2961 ± 1261 ± 12NRNRBM / ADAuto12
6Freitag et al[27], 2019AustraliaRCTII, III3020/1054.6 ± 6.351.5 ± 6.111/0901/09ADAuto 12
7Ruane et al[41], 2021United StatesRCTI, II, III3217/1558.06 ± 9.14 58.6 ± 8.0509/0810/05BMAuto12
8Lamo-Espinosa et al[28], 2016SpainRCTII, III, IV 3020/1065.960.312/0807/03BMAuto12
9Garza et al[29], 2020United StatesRCTII, III3926/1360.5 ± 7.957.1 ± 9.115/117/6ADAuto12
10Wong et al[30], 2013SingaporeRCTNR5628/28534915/1314/14BMAuto24
11Lu et al[31], 2019ChinaRCTI, II, III5327/2655.03 ± 9.1959.64 ± 5.9703/2403/23ADAuto 12
12Lv et al[42], 2015HuangRCTI, II8040/4055.9 ± 8.155.1 ± 6.814/2613/27BMAuto12
13Emadedin et al[32], 2018Iran RCTII, III, IV 4319/2451.7 ± 9.254.7 ± 5.312/0715/09BMAuto6
14Gupta et al[33], 2016IndiaRCTII, III6040/2058.10 ± 8.2354.90 ± 8.2712/284/16BMAllo12
15Bastos et al[34], 2020Brazil RCTI, II, III, IV4730/1755.7 ± 7.855.9 ± 13.415/1509/08BMAuto12
16Wakitani et al[35], 2002JapanI, II2412/12NRNRNRNRBMAuto16
17Tran et al[36], 2019TaiwanRCTII, III3315/1858.2 ± 5.7059.0 ± 6.0403/1205/13ADAuto24
18Lee et al[37], 2019South KoreaRCTII, III, IV 2412/1262.2 ± 6.563.2 ± 4.203/0903/09ADAuto6
19Koh et al[38], 2012South KoreaRCTIV5025/2554.2 ± 9.354.4 ± 11.308/1708/17ADAuto16
20Koh et al[39], 2014South KoreaRCTI, II, III4423/2152.3 ± 4.954.2 ± 2.906/1705/16ADAuto 24
21Hong et al[40], 2019ChinaRCTII, III3216/1651 ± 5.9553 ± 10.9703/1303/13ADAuto12
Table 2 Stem cell transplantation protocol of the included studies
Ref.
MSC type
MSC source
MSC preparation
MSC count (107 cells)
Treatment group intervention
Control group intervention
Outcome measures
Vega et al[23], 2015BMAlloCE-BMMSC4sIA injection of MSCsIA Injection of 60 mg HAVAS, WOMAC
Vangsness et al[24], 2014BMAlloCE-BMMSC5/15sIA injection of MSC + 20 mg HAsIA Injection of 20 mg HAVAS, Lysholm Score
Garay-Mendoza et al[25], 2018BMAutoBMCNA600 μg/d G-CSF for 3 consecutive days before the procedure + sIA injection of MSCOral acetaminophen, 500 mg every 8 h for 6 moVAS, WOMAC
Kuah et al[26], 2018ADAlloCE-ADMSC0.39-0.67sIA injection of MSCPlacebo sIA injection of cell culture media and cryopreservativeVAS, WOMAC, MRI assessment
Estrada et al[22], 2020ADAutoBMCNAsIA injection of BM concentratesIA injection of PRPIKDC, Lysholm Score, KOOS
Estrada et al[22], 2020BMAutoSVFNAsIA injection of lipoaspiratesIA injection of PRP
Freitag et al[27], 2019ADAuto CE-ADMSC10sIA injection of MSC ± 2nd injection at 6 moConservative managementVAS, WOMAC, KOOS, MRI assessment
Ruane et al[41], 2021BMAutoBMCNAsIA injection of BM concentrate + PRPGel-One® Cross-Linked hyaluronate injectionVAS, KOOS
Lamo-Espinosa et al[28], 2016BMAutoCE-BMMSC1sIA injection of MSC + 60 mg HAsIA injection of 60 mg HAVAS, WOMAC, MRI assessment
Garza et al[29], 2020ADAutoSVFNAsIA injection of MSCPlacebo injection without cellsWOMAC, MRI assessment
Wong et al[30], 2013BMAutoCE-BMMSC1.46HTO + microfracture + sIA injection of MSC + 20 mg HAHTO + microfracture + sIA injection of 20 mg HATegner Score, Lysholm Score
Lu et al[31], 2019ADAuto CE-ADMSC52 IA injection of MSC at 0, 3 wk and sham injection at 1, 2 wk4 IA injection of 25 mg HA at 0, 1, 2, 3 wkVAS, WOMAC
Lv et al[42], 2015BMAutoCE-BMMSC3.823 × monthly IA injection of MSC + 20 mg HAsIA injection of 20 mg HATegner Score, Lysholm Score
Emadedin et al[32], 2018BMAutoCE-BMMSC4sIA injection of MSCPlacebo sIA injection of normal salineVAS, WOMAC
Gupta et al[33], 2016BMAlloCE-BMMSC2.5-15sIA injection of MSC + 20 mg HAPlacebo sIA injection of 20 mg HAVAS, WOMAC, MRI assessment
Bastos et al[34], 2020BMAutoCE-BMMSC4sIA injection of MSC in 10 mL of PRPsIA injection of 4 mg dexamethasoneKOOS, MRI assessment
Wakitani et al[35], 2002BMAutoCE-BMMSC1HTO + microfracture + sIA injection of MSCHTO + microfracture + placebo injectionMRI assessment, HSS knee rating scale
Tran et al[36], 2019ADAutoSVFNAArthroscopic micro fracture + sIA injection of MSCArthroscopic micro fractureWOMAC, MRI assessment
Lee et al[37], 2019ADAutoCE-ADMSC10sIA injection of MSCPlacebo injection with normal salineWOMAC, MRI assessment
Koh et al[38], 2012ADAutoSVF0.189Arthroscopic debridement + sIA injection of MSC + PRPArthroscopic debridement + PRPVAS, Tegner Score, Lysholm Score
Koh et al[39], 2014ADAuto CE-ADMSC0.411HTO + sIA injection of MSC + PRPHTO + PRPVAS, Lysholm Score
Hong et al[40], 2019ADAutoSVF0.745sIA injection of MSCsIA injection of 40 mg HAVAS, WOMAC, MRI assessment